EIF2S2

Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa, also known as EIF2S2, is a human gene.cite web | title = Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8894| accessdate = ] cite journal | author = Pathak VK, Nielsen PJ, Trachsel H, Hershey JW | title = Structure of the beta subunit of translational initiation factor eIF-2 | journal = Cell | volume = 54 | issue = 5 | pages = 633–9 | year = 1988 | month = August | pmid = 3044606 | doi = 10.1016/S0092-8674(88)80007-2 | url = | issn = ]

Function

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta (this article), and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.

Regulation

Both eIF2-alpha and eIF2-beta expression is regulated by the the NRF1 transcription factor.cite journal | author = Chiorini JA, Miyamoto S, Harkin SJ, Safer B | title = Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter | journal = J. Biol. Chem. | volume = 274 | issue = 7 | pages = 4195–201 | year = 1999 | month = February | pmid = 9933616 | doi = 10.1074/jbc.274.7.4195 | url = | issn = ]

ee also

* eIF2

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pathak VK, Nielsen PJ, Trachsel H, Hershey JW |title=Structure of the beta subunit of translational initiation factor eIF-2. |journal=Cell |volume=54 |issue= 5 |pages= 633–9 |year= 1988 |pmid= 3044606 |doi=
*cite journal | author=Welsh GI, Price NT, Bladergroen BA, "et al." |title=Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1279–88 |year= 1994 |pmid= 8024572 |doi= 10.1006/bbrc.1994.1843
*cite journal | author=Brand SR, Kobayashi R, Mathews MB |title=The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8388–95 |year= 1997 |pmid= 9079663 |doi=
*cite journal | author=Das S, Maiti T, Das K, Maitra U |title=Specific interaction of eukaryotic translation initiation factor 5 (eIF5) with the beta-subunit of eIF2. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31712–8 |year= 1998 |pmid= 9395514 |doi=
*cite journal | author=Ting NS, Kao PN, Chan DW, "et al." |title=DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2136–45 |year= 1998 |pmid= 9442054 |doi=
*cite journal | author=Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS |title=Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 3039–44 |year= 1998 |pmid= 9446619 |doi=
*cite journal | author=Chiorini JA, Miyamoto S, Harkin SJ, Safer B |title=Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4195–201 |year= 1999 |pmid= 9933616 |doi=
*cite journal | author=Cai R, Carpick B, Chun RF, "et al." |title=HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms. |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 361–7 |year= 2000 |pmid= 10620360 |doi= 10.1006/abbi.1999.1583
*cite journal | author=Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R |title=Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 1011–8 |year= 2000 |pmid= 10648795 |doi=
*cite journal | author=Das S, Maitra U |title=Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3942–50 |year= 2000 |pmid= 10805737 |doi=
*cite journal | author=Gomez E, Pavitt GD |title=Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3965–76 |year= 2000 |pmid= 10805739 |doi=
*cite journal | author=Das S, Ghosh R, Maitra U |title=Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6720–6 |year= 2001 |pmid= 11092890 |doi= 10.1074/jbc.M008863200
*cite journal | author=Reichman TW, Muñiz LC, Mathews MB |title=The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 343–56 |year= 2002 |pmid= 11739746 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Kebache S, Zuo D, Chevet E, Larose L |title=Modulation of protein translation by Nck-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5406–11 |year= 2002 |pmid= 11959995 |doi= 10.1073/pnas.082483399
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Llorens F, Roher N, Miró FA, "et al." |title=Eukaryotic translation-initiation factor eIF2beta binds to protein kinase CK2: effects on CK2alpha activity. |journal=Biochem. J. |volume=375 |issue= Pt 3 |pages= 623–31 |year= 2004 |pmid= 12901717 |doi= 10.1042/BJ20030915
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029

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