- EFNA2
Ephrin-A2, also known as EFNA2, is a human
gene .cite web | title = Entrez Gene: EFNA2 ephrin-A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1943| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.cite web | title = Entrez Gene: EFNA2 ephrin-A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1943| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Cerretti DP, Nelson N |title=Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure. |journal=Genomics |volume=47 |issue= 1 |pages= 131–5 |year= 1998 |pmid= 9465306 |doi= 10.1006/geno.1997.5088
*cite journal | author=Ciossek T, Monschau B, Kremoser C, "et al." |title=Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. |journal=Eur. J. Neurosci. |volume=10 |issue= 5 |pages= 1574–80 |year= 1998 |pmid= 9751130 |doi=
*cite journal | author=Aasheim HC, Pedeutour F, Grosgeorge J, Logtenberg T |title=Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 2 |pages= 378–82 |year= 1998 |pmid= 9826538 |doi= 10.1006/bbrc.1998.9618
*cite journal | author=Gerlai R, Shinsky N, Shih A, "et al." |title=Regulation of learning by EphA receptors: a protein targeting study. |journal=J. Neurosci. |volume=19 |issue= 21 |pages= 9538–49 |year= 1999 |pmid= 10531456 |doi=
*cite journal | author=Hattori M, Osterfield M, Flanagan JG |title=Regulated cleavage of a contact-mediated axon repellent. |journal=Science |volume=289 |issue= 5483 |pages= 1360–5 |year= 2000 |pmid= 10958785 |doi=
*cite journal | author=Rodger J, Lindsey KA, Leaver SG, "et al." |title=Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat. |journal=Eur. J. Neurosci. |volume=14 |issue= 12 |pages= 1929–36 |year= 2002 |pmid= 11860487 |doi=PBB_Controls
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