CUL4B

Cullin 4B, also known as CUL4B, is a human gene.cite web | title = Entrez Gene: CUL4B cullin 4B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8450| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: CUL4B cullin 4B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8450| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Kipreos ET, Lander LE, Wing JP, "et al." |title=cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. |journal=Cell |volume=85 |issue= 6 |pages= 829–39 |year= 1996 |pmid= 8681378 |doi=
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Wada H, Yeh ET, Kamitani T |title=Identification of NEDD8-conjugation site in human cullin-2. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 1 |pages= 100–5 |year= 1999 |pmid= 10092517 |doi= 10.1006/bbrc.1999.0339
*cite journal | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535–41 |year= 1999 |pmid= 10230407 |doi=
*cite journal | author=Hori T, Osaka F, Chiba T, "et al." |title=Covalent modification of all members of human cullin family proteins by NEDD8. |journal=Oncogene |volume=18 |issue= 48 |pages= 6829–34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093
*cite journal | author=Jones EA, Clement-Jones M, Wilson DI |title=JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype. |journal=J. Med. Genet. |volume=37 |issue= 9 |pages= 658–62 |year= 2000 |pmid= 10978356 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zheng J, Yang X, Harrell JM, "et al." |title=CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. |journal=Mol. Cell |volume=10 |issue= 6 |pages= 1519–26 |year= 2003 |pmid= 12504026 |doi=
*cite journal | author=Min KW, Hwang JW, Lee JS, "et al." |title=TIP120A associates with cullins and modulates ubiquitin ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15905–10 |year= 2003 |pmid= 12609982 |doi= 10.1074/jbc.M213070200
*cite journal | author=Higa LA, Mihaylov IS, Banks DP, "et al." |title=Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. |journal=Nat. Cell Biol. |volume=5 |issue= 11 |pages= 1008–15 |year= 2004 |pmid= 14578910 |doi= 10.1038/ncb1061
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Higa LA, Yang X, Zheng J, "et al." |title=Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. |journal=Cell Cycle |volume=5 |issue= 1 |pages= 71–7 |year= 2006 |pmid= 16322693 |doi=
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Senga T, Sivaprasad U, Zhu W, "et al." |title=PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. |journal=J. Biol. Chem. |volume=281 |issue= 10 |pages= 6246–52 |year= 2006 |pmid= 16407252 |doi= 10.1074/jbc.M512705200
*cite journal | author=Li T, Santockyte R, Shen RF, "et al." |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70–4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002
*cite journal | author=Wang H, Zhai L, Xu J, "et al." |title=Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. |journal=Mol. Cell |volume=22 |issue= 3 |pages= 383–94 |year= 2006 |pmid= 16678110 |doi= 10.1016/j.molcel.2006.03.035

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