PREP (gene)

PREP (gene)

Prolyl endopeptidase, also known as PREP, is a human gene.cite web | title = Entrez Gene: PREP prolyl endopeptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5550| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.cite web | title = Entrez Gene: PREP prolyl endopeptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5550| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mentlein R |title=Proline residues in the maturation and degradation of peptide hormones and neuropeptides. |journal=FEBS Lett. |volume=234 |issue= 2 |pages= 251–6 |year= 1988 |pmid= 3292288 |doi=
*cite journal | author=Wilk S |title=Prolyl endopeptidase. |journal=Life Sci. |volume=33 |issue= 22 |pages= 2149–57 |year= 1984 |pmid= 6358755 |doi=
*cite journal | author=Koida M, Walter R |title=Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography. |journal=J. Biol. Chem. |volume=251 |issue= 23 |pages= 7593–9 |year= 1977 |pmid= 12173 |doi=
*cite journal | author=Swanson AA, Davis RM, Meinhardt NC |title=Proteases in human lenses and their possible significance. |journal=Curr. Eye Res. |volume=4 |issue= 1 |pages= 43–8 |year= 1985 |pmid= 2858361 |doi=
*cite journal | author=Momand J, Clarke S |title=Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes. |journal=Biochemistry |volume=26 |issue= 24 |pages= 7798–805 |year= 1988 |pmid= 3480758 |doi=
*cite journal | author=Checler F, Vincent JP, Kitabgi P |title=Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes. |journal=J. Biol. Chem. |volume=261 |issue= 24 |pages= 11274–81 |year= 1986 |pmid= 3525564 |doi=
*cite journal | author=Daly DJ, Maskrey P, Pennington RJ |title=Characterization of proline endopeptidase from skeletal muscle. |journal=Int. J. Biochem. |volume=17 |issue= 4 |pages= 521–4 |year= 1985 |pmid= 3891453 |doi=
*cite journal | author=Sumi S, Mizutani S, Narita O, Tomoda Y |title=Purification and properties of a human placental post-proline endopeptidase. |journal=Nippon Sanka Fujinka Gakkai Zasshi |volume=36 |issue= 10 |pages= 1943–51 |year= 1985 |pmid= 6389730 |doi=
*cite journal | author=Goossens F, De Meester I, Vanhoof G, "et al." |title=The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family. |journal=Eur. J. Biochem. |volume=233 |issue= 2 |pages= 432–41 |year= 1995 |pmid= 7588785 |doi=
*cite journal | author=Vanhoof G, Goossens F, Hendriks L, "et al." |title=Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. |journal=Gene |volume=149 |issue= 2 |pages= 363–6 |year= 1994 |pmid= 7959018 |doi=
*cite journal | author=Shirasawa Y, Osawa T, Hirashima A |title=Molecular cloning and characterization of prolyl endopeptidase from human T cells. |journal=J. Biochem. |volume=115 |issue= 4 |pages= 724–9 |year= 1994 |pmid= 8089089 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Goossens FJ, Wauters JG, Vanhoof GC, "et al." |title=Subregional mapping of the human lymphocyte prolyl oligopeptidase gene (PREP) to human chromosome 6q22. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 1-2 |pages= 99–101 |year= 1996 |pmid= 8893811 |doi=
*cite journal | author=Fülöp V, Böcskei Z, Polgár L |title=Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. |journal=Cell |volume=94 |issue= 2 |pages= 161–70 |year= 1998 |pmid= 9695945 |doi=
*cite journal | author=Quinto BM, Juliano MA, Hirata I, "et al." |title=Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 11-12 |pages= 1161–72 |year= 2001 |pmid= 11137456 |doi=
*cite journal | author=Irazusta J, Larrinaga G, González-Maeso J, "et al." |title=Distribution of prolyl endopeptidase activities in rat and human brain. |journal=Neurochem. Int. |volume=40 |issue= 4 |pages= 337–45 |year= 2002 |pmid= 11792464 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bellemère G, Morain P, Vaudry H, Jégou S |title=Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. |journal=J. Neurochem. |volume=84 |issue= 5 |pages= 919–29 |year= 2003 |pmid= 12603817 |doi=

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