TREM1

Triggering receptor expressed on myeloid cells 1, also known as TREM1, is a human gene.cite web | title = Entrez Gene: TREM1 triggering receptor expressed on myeloid cells 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54210| accessdate = ]

PBB_Summary
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summary_text = Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936). [supplied by OMIM] cite web | title = Entrez Gene: TREM1 triggering receptor expressed on myeloid cells 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54210| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bouchon A, Dietrich J, Colonna M |title=Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. |journal=J. Immunol. |volume=164 |issue= 10 |pages= 4991–5 |year= 2000 |pmid= 10799849 |doi=
*cite journal | author=Bouchon A, Facchetti F, Weigand MA, Colonna M |title=TREM-1 amplifies inflammation and is a crucial mediator of septic shock. |journal=Nature |volume=410 |issue= 6832 |pages= 1103–7 |year= 2001 |pmid= 11323674 |doi= 10.1038/35074114
*cite journal | author=Gingras MC, Lapillonne H, Margolin JF |title=TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development. |journal=Mol. Immunol. |volume=38 |issue= 11 |pages= 817–24 |year= 2002 |pmid= 11922939 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Allcock RJ, Barrow AD, Forbes S, "et al." |title=The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. |journal=Eur. J. Immunol. |volume=33 |issue= 2 |pages= 567–77 |year= 2003 |pmid= 12645956 |doi= 10.1002/immu.200310033
*cite journal | author=Bleharski JR, Kiessler V, Buonsanti C, "et al." |title=A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. |journal=J. Immunol. |volume=170 |issue= 7 |pages= 3812–8 |year= 2003 |pmid= 12646648 |doi=
*cite journal | author=Colonna M, Facchetti F |title=TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. |journal=J. Infect. Dis. |volume=187 Suppl 2 |issue= |pages= S397–401 |year= 2003 |pmid= 12792857 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Radaev S, Kattah M, Rostro B, "et al." |title=Crystal structure of the human myeloid cell activating receptor TREM-1. |journal=Structure |volume=11 |issue= 12 |pages= 1527–35 |year= 2004 |pmid= 14656437 |doi=
*cite journal | author=Radsak MP, Salih HR, Rammensee HG, Schild H |title=Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. |journal=J. Immunol. |volume=172 |issue= 8 |pages= 4956–63 |year= 2004 |pmid= 15067076 |doi=
*cite journal | author=Wang DY, Qin RY, Liu ZR, "et al." |title=Expression of TREM-1 mRNA in acute pancreatitis. |journal=World J. Gastroenterol. |volume=10 |issue= 18 |pages= 2744–6 |year= 2004 |pmid= 15309732 |doi=
*cite journal | author=Kelker MS, Foss TR, Peti W, "et al." |title=Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. |journal=J. Mol. Biol. |volume=342 |issue= 4 |pages= 1237–48 |year= 2004 |pmid= 15351648 |doi= 10.1016/j.jmb.2004.07.089
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Knapp S, Gibot S, de Vos A, "et al." |title=Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. |journal=J. Immunol. |volume=173 |issue= 12 |pages= 7131–4 |year= 2005 |pmid= 15585833 |doi=
*cite journal | author=González-Roldán N, Ferat-Osorio E, Aduna-Vicente R, "et al." |title=Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery. |journal=World J. Gastroenterol. |volume=11 |issue= 47 |pages= 7473–9 |year= 2006 |pmid= 16437719 |doi=
*cite journal | author=Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ, "et al." |title=Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease. |journal=World J. Gastroenterol. |volume=12 |issue= 21 |pages= 3416–9 |year= 2006 |pmid= 16733861 |doi=
*cite journal | author=Plachouras D, Routsi C, Giamarellos-Bourboulis EJ, "et al." |title=Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the septic host. |journal=Scand. J. Infect. Dis. |volume=38 |issue= 10 |pages= 909–15 |year= 2006 |pmid= 17008237 |doi= 10.1080/00365540600786523
*cite journal | author=Murakami Y, Kohsaka H, Kitasato H, Akahoshi T |title=Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin E2. |journal=J. Immunol. |volume=178 |issue= 2 |pages= 1144–50 |year= 2007 |pmid= 17202378 |doi=

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