PIK3CD

Phosphoinositide-3-kinase, catalytic, delta polypeptide, also known as PIK3CD, is a human gene.cite web | title = Entrez Gene: PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5293| accessdate = ]

PBB_Summary
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summary_text = Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras. [supplied by OMIM] cite web | title = Entrez Gene: PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5293| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee C, Liu QH, Tomkowicz B, "et al." |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206
*cite journal | author=Rommel C, Camps M, Ji H |title=PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? |journal=Nat. Rev. Immunol. |volume=7 |issue= 3 |pages= 191–201 |year= 2007 |pmid= 17290298 |doi= 10.1038/nri2036
*cite journal | author=Milani D, Mazzoni M, Borgatti P, "et al." |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Vanhaesebroeck B, Welham MJ, Kotani K, "et al." |title=P110delta, a novel phosphoinositide 3-kinase in leukocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4330–5 |year= 1997 |pmid= 9113989 |doi=
*cite journal | author=Chantry D, Vojtek A, Kashishian A, "et al." |title=p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19236–41 |year= 1997 |pmid= 9235916 |doi=
*cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=
*cite journal | author=Borgatti P, Zauli G, Colamussi ML, "et al." |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=
*cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=
*cite journal | author=Seki N, Nimura Y, Ohira M, "et al." |title=Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase. |journal=DNA Res. |volume=4 |issue= 5 |pages= 355–8 |year= 1998 |pmid= 9455486 |doi=
*cite journal | author=Milani D, Mazzoni M, Zauli G, "et al." |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=
*cite journal | author=Jauliac S, Mazerolles F, Jabado N, "et al." |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=
*cite journal | author=Vanhaesebroeck B, Higashi K, Raven C, "et al." |title=Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1292–302 |year= 1999 |pmid= 10064595 |doi= 10.1093/emboj/18.5.1292
*cite journal | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=
*cite journal | author=Zauli G, Milani D, Mirandola P, "et al." |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com
*cite journal | author=Deregibus MC, Cantaluppi V, Doublier S, "et al." |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200
*cite journal | author=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=François F, Klotman ME |title=Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. |journal=J. Virol. |volume=77 |issue= 4 |pages= 2539–49 |year= 2003 |pmid= 12551992 |doi=
*cite journal | author=Sadhu C, Masinovsky B, Dick K, "et al." |title=Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. |journal=J. Immunol. |volume=170 |issue= 5 |pages= 2647–54 |year= 2003 |pmid= 12594293 |doi=

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