GIT2

G protein-coupled receptor kinase interactor 2, also known as GIT2, is a human gene.cite web | title = Entrez Gene: GIT2 G protein-coupled receptor kinase interactor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9815| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length sequence has been determined for only four variants. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.cite web | title = Entrez Gene: GIT2 G protein-coupled receptor kinase interactor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9815| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Hoefen RJ, Berk BC |title=The multifunctional GIT family of proteins. |journal=J. Cell. Sci. |volume=119 |issue= Pt 8 |pages= 1469–75 |year= 2006 |pmid= 16598076 |doi= 10.1242/jcs.02925
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Premont RT, Claing A, Vitale N, "et al." |title=beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14082–7 |year= 1998 |pmid= 9826657 |doi=
*cite journal | author=Turner CE, Brown MC, Perrotta JA, "et al." |title=Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 851–63 |year= 1999 |pmid= 10330411 |doi=
*cite journal | author=Bagrodia S, Bailey D, Lenard Z, "et al." |title=A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22393–400 |year= 1999 |pmid= 10428811 |doi=
*cite journal | author=Vitale N, Patton WA, Moss J, "et al." |title=GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13901–6 |year= 2000 |pmid= 10788515 |doi=
*cite journal | author=Premont RT, Claing A, Vitale N, "et al." |title=The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22373–80 |year= 2000 |pmid= 10896954 |doi=
*cite journal | author=Hoja MR, Wahlestedt C, Höög C |title=A visual intracellular classification strategy for uncharacterized human proteins. |journal=Exp. Cell Res. |volume=259 |issue= 1 |pages= 239–46 |year= 2000 |pmid= 10942595 |doi= 10.1006/excr.2000.4948
*cite journal | author=Ku GM, Yablonski D, Manser E, "et al." |title=A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. |journal=EMBO J. |volume=20 |issue= 3 |pages= 457–65 |year= 2001 |pmid= 11157752 |doi= 10.1093/emboj/20.3.457
*cite journal | author=Mazaki Y, Hashimoto S, Okawa K, "et al." |title=An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. |journal=Mol. Biol. Cell |volume=12 |issue= 3 |pages= 645–62 |year= 2001 |pmid= 11251077 |doi=
*cite journal | author=Kim S, Ko J, Shin H, "et al." |title=The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6291–300 |year= 2003 |pmid= 12473661 |doi= 10.1074/jbc.M212287200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Premont RT, Perry SJ, Schmalzigaug R, "et al." |title=The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. |journal=Cell. Signal. |volume=16 |issue= 9 |pages= 1001–11 |year= 2005 |pmid= 15212761 |doi= 10.1016/j.cellsig.2004.02.002
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051

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