ARHGEF6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6, also known as ARHGEF6, is a human gene.cite web | title = Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9459| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.cite web | title = Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9459| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 5 |pages= 251–62 |year= 1995 |pmid= 7584048 |doi=
*cite journal | author=Ebinu JO, Bottorff DA, Chan EY, "et al." |title=RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. |journal=Science |volume=280 |issue= 5366 |pages= 1082–6 |year= 1998 |pmid= 9582122 |doi=
*cite journal | author=Manser E, Loo TH, Koh CG, "et al." |title=PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. |journal=Mol. Cell |volume=1 |issue= 2 |pages= 183–92 |year= 1998 |pmid= 9659915 |doi=
*cite journal | author=Yntema HG, Hamel BC, Smits AP, "et al." |title=Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26. |journal=J. Med. Genet. |volume=35 |issue= 10 |pages= 801–5 |year= 1999 |pmid= 9783701 |doi=
*cite journal | author=Yoshii S, Tanaka M, Otsuki Y, "et al." |title=alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase. |journal=Oncogene |volume=18 |issue= 41 |pages= 5680–90 |year= 1999 |pmid= 10523848 |doi= 10.1038/sj.onc.1202936
*cite journal | author=Brown A, Wang X, Sawai E, Cheng-Mayer C |title=Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex. |journal=J. Virol. |volume=73 |issue= 12 |pages= 9899–907 |year= 1999 |pmid= 10559302 |doi=
*cite journal | author=Premont RT, Claing A, Vitale N, "et al." |title=The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22373–80 |year= 2000 |pmid= 10896954 |doi=
*cite journal | author=Kutsche K, Yntema H, Brandt A, "et al." |title=Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. |journal=Nat. Genet. |volume=26 |issue= 2 |pages= 247–50 |year= 2000 |pmid= 11017088 |doi= 10.1038/80002
*cite journal | author=Lower KM, Gecz J |title=Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27. |journal=Am. J. Med. Genet. |volume=100 |issue= 1 |pages= 43–8 |year= 2001 |pmid= 11337747 |doi=
*cite journal | author=Yoshii S, Tanaka M, Otsuki Y, "et al." |title=Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo [a] pyrene. |journal=Mol. Cell. Biol. |volume=21 |issue= 20 |pages= 6796–807 |year= 2001 |pmid= 11564864 |doi= 10.1128/MCB.21.20.6796-6807.2001
*cite journal | author=Vikis HG, Li W, Guan KL |title=The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. |journal=Genes Dev. |volume=16 |issue= 7 |pages= 836–45 |year= 2002 |pmid= 11937491 |doi= 10.1101/gad.966402
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155–67 |year= 2003 |pmid= 12499396 |doi=
*cite journal | author=Flanders JA, Feng Q, Bagrodia S, "et al." |title=The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. |journal=FEBS Lett. |volume=550 |issue= 1-3 |pages= 119–23 |year= 2003 |pmid= 12935897 |doi=
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Djordjevic T, Hess J, Herkert O, "et al." |title=Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway. |journal=Antioxid. Redox Signal. |volume=6 |issue= 4 |pages= 713–20 |year= 2005 |pmid= 15242552 |doi= 10.1089/1523086041361703
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051

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