THBS2

Thrombospondin 2, also known as THBS2, is a human gene.cite web | title = Entrez Gene: THBS2 thrombospondin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7058| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.cite web | title = Entrez Gene: THBS2 thrombospondin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7058| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bornstein P, Kyriakides TR, Yang Z, "et al." |title=Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis. |journal=J. Investig. Dermatol. Symp. Proc. |volume=5 |issue= 1 |pages= 61–6 |year= 2001 |pmid= 11147677 |doi= 10.1046/j.1087-0024.2000.00005.x
*cite journal | author=O'Rourke KM, Laherty CD, Dixit VM |title=Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers. |journal=J. Biol. Chem. |volume=267 |issue= 35 |pages= 24921–4 |year= 1993 |pmid= 1459996 |doi=
*cite journal | author=LaBell TL, Milewicz DJ, Disteche CM, Byers PH |title=Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans. |journal=Genomics |volume=12 |issue= 3 |pages= 421–9 |year= 1992 |pmid= 1559694 |doi=
*cite journal | author=LaBell TL, Byers PH |title=Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region. |journal=Genomics |volume=17 |issue= 1 |pages= 225–9 |year= 1993 |pmid= 8406456 |doi= 10.1006/geno.1993.1308
*cite journal | author=Adolph KW, Liska DJ, Bornstein P |title=Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2). |journal=Gene |volume=193 |issue= 1 |pages= 5–11 |year= 1997 |pmid= 9249061 |doi=
*cite journal | author=Kyriakides TR, Zhu YH, Smith LT, "et al." |title=Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. |journal=J. Cell Biol. |volume=140 |issue= 2 |pages= 419–30 |year= 1998 |pmid= 9442117 |doi=
*cite journal | author=Adolph KW |title=Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues. |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 792–6 |year= 1999 |pmid= 10329465 |doi= 10.1006/bbrc.1999.0710
*cite journal | author=Carron JA, Bowler WB, Wagstaff SC, Gallagher JA |title=Expression of members of the thrombospondin family by human skeletal tissues and cultured cells. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 2 |pages= 389–91 |year= 1999 |pmid= 10491303 |doi= 10.1006/bbrc.1999.1380
*cite journal | author=Bein K, Simons M |title=Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32167–73 |year= 2000 |pmid= 10900205 |doi= 10.1074/jbc.M003834200
*cite journal | author=Hawighorst T, Velasco P, Streit M, "et al." |title=Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. |journal=EMBO J. |volume=20 |issue= 11 |pages= 2631–40 |year= 2001 |pmid= 11387198 |doi= 10.1093/emboj/20.11.2631
*cite journal | author=Misenheimer TM, Hahr AJ, Harms AC, "et al." |title=Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 45882–7 |year= 2002 |pmid= 11590138 |doi= 10.1074/jbc.M104218200
*cite journal | author=Armstrong DJ, Hiscott P, Batterbury M, Kaye S |title=Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 6 |pages= 588–93 |year= 2002 |pmid= 11943589 |doi=
*cite journal | author=Li Z, Calzada MJ, Sipes JM, "et al." |title=Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 509–19 |year= 2002 |pmid= 11980922 |doi= 10.1083/jcb.200109098
*cite journal | author=Armstrong LC, Björkblom B, Hankenson KD, "et al." |title=Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism. |journal=Mol. Biol. Cell |volume=13 |issue= 6 |pages= 1893–905 |year= 2002 |pmid= 12058057 |doi= 10.1091/mbc.E01-09-0066.
*cite journal | author=Hatakeyama H, Nishizawa M, Nakagawa A, "et al." |title=Thrombospondin expression in aldosterone-producing adenomas. |journal=Hypertens. Res. |volume=25 |issue= 4 |pages= 523–7 |year= 2003 |pmid= 12358136 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Boekholdt SM, Trip MD, Peters RJ, "et al." |title=Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=22 |issue= 12 |pages= e24–7 |year= 2002 |pmid= 12482844 |doi=
*cite journal | author=Kyriakides TR, Rojnuckarin P, Reidy MA, "et al." |title=Megakaryocytes require thrombospondin-2 for normal platelet formation and function. |journal=Blood |volume=101 |issue= 10 |pages= 3915–23 |year= 2003 |pmid= 12732502 |doi= 10.1182/blood.V101.10.3915
*cite journal | author=Kishi M, Nakamura M, Nishimine M, "et al." |title=Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas. |journal=Cancer Sci. |volume=94 |issue= 6 |pages= 530–5 |year= 2003 |pmid= 12824879 |doi=

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