TFAM

TFAM

Transcription factor A, mitochondrial, also known as TFAM, is a human gene.cite web | title = Entrez Gene: TFAM transcription factor A, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7019| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.cite web | title = Entrez Gene: TFAM transcription factor A, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7019| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tominaga K, Akiyama S, Kagawa Y, Ohta S |title=Upstream region of a genomic gene for human mitochondrial transcription factor 1. |journal=Biochim. Biophys. Acta |volume=1131 |issue= 2 |pages= 217–9 |year= 1992 |pmid= 1610904 |doi=
*cite journal | author=Fisher RP, Lisowsky T, Parisi MA, Clayton DA |title=DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3358–67 |year= 1992 |pmid= 1737790 |doi=
*cite journal | author=Parisi MA, Clayton DA |title=Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. |journal=Science |volume=252 |issue= 5008 |pages= 965–9 |year= 1991 |pmid= 2035027 |doi=
*cite journal | author=Tiranti V, Rossi E, Ruiz-Carrillo A, "et al." |title=Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. |journal=Genomics |volume=25 |issue= 2 |pages= 559–64 |year= 1995 |pmid= 7789991 |doi=
*cite journal | author=Tominaga K, Hayashi J, Kagawa Y, Ohta S |title=Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing. |journal=Biochem. Biophys. Res. Commun. |volume=194 |issue= 1 |pages= 544–51 |year= 1993 |pmid= 8333869 |doi= 10.1006/bbrc.1993.1854
*cite journal | author=Larsson NG, Oldfors A, Garman JD, "et al." |title=Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans. |journal=Hum. Mol. Genet. |volume=6 |issue= 2 |pages= 185–91 |year= 1997 |pmid= 9063738 |doi=
*cite journal | author=Lezza AM, Pesce V, Cormio A, "et al." |title=Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. |journal=FEBS Lett. |volume=501 |issue= 1 |pages= 74–8 |year= 2001 |pmid= 11457459 |doi=
*cite journal | author=Takamatsu C, Umeda S, Ohsato T, "et al." |title=Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. |journal=EMBO Rep. |volume=3 |issue= 5 |pages= 451–6 |year= 2002 |pmid= 11964388 |doi= 10.1093/embo-reports/kvf099
*cite journal | author=Falkenberg M, Gaspari M, Rantanen A, "et al." |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909
*cite journal | author=Reyes A, Mezzina M, Gadaleta G |title=Human mitochondrial transcription factor A (mtTFA): gene structure and characterization of related pseudogenes. |journal=Gene |volume=291 |issue= 1-2 |pages= 223–32 |year= 2002 |pmid= 12095695 |doi=
*cite journal | author=Yoshida Y, Izumi H, Ise T, "et al." |title=Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 945–51 |year= 2002 |pmid= 12127986 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Garrido N, Griparic L, Jokitalo E, "et al." |title=Composition and dynamics of human mitochondrial nucleoids. |journal=Mol. Biol. Cell |volume=14 |issue= 4 |pages= 1583–96 |year= 2003 |pmid= 12686611 |doi= 10.1091/mbc.E02-07-0399
*cite journal | author=Yoshida Y, Izumi H, Torigoe T, "et al." |title=P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3729–34 |year= 2003 |pmid= 12839966 |doi=
*cite journal | author=McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5816–24 |year= 2003 |pmid= 12897151 |doi=
*cite journal | author=Deschauer M, Kiefer R, Blakely EL, "et al." |title=A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia. |journal=Neuromuscul. Disord. |volume=13 |issue= 7-8 |pages= 568–72 |year= 2003 |pmid= 12921794 |doi=
*cite journal | author=Günther C, von Hadeln K, Müller-Thomsen T, "et al." |title=Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease. |journal=Neurosci. Lett. |volume=369 |issue= 3 |pages= 219–23 |year= 2005 |pmid= 15464268 |doi= 10.1016/j.neulet.2004.07.070
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kanki T, Ohgaki K, Gaspari M, "et al." |title=Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. |journal=Mol. Cell. Biol. |volume=24 |issue= 22 |pages= 9823–34 |year= 2004 |pmid= 15509786 |doi= 10.1128/MCB.24.22.9823-9834.2004
*cite journal | author=Cam H, Balciunaite E, Blais A, "et al." |title=A common set of gene regulatory networks links metabolism and growth inhibition. |journal=Mol. Cell |volume=16 |issue= 3 |pages= 399–411 |year= 2004 |pmid= 15525513 |doi= 10.1016/j.molcel.2004.09.037

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