EPHA3

EPH receptor A3, also known as EPHA3, is a human gene.cite web | title = Entrez Gene: EPHA3 EPH receptor A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2042| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.cite web | title = Entrez Gene: EPHA3 EPH receptor A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2042| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Ernst AF, Jurney WM, McLoon SC |title=Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide. |journal=Prog. Brain Res. |volume=118 |issue= |pages= 115–31 |year= 1999 |pmid= 9932438 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Wicks IP, Wilkinson D, Salvaris E, Boyd AW |title=Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1611–5 |year= 1992 |pmid= 1311845 |doi=
*cite journal | author=Boyd AW, Ward LD, Wicks IP, "et al." |title=Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3262–7 |year= 1992 |pmid= 1737782 |doi=
*cite journal | author=Beckmann MP, Cerretti DP, Baum P, "et al." |title=Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3757–62 |year= 1994 |pmid= 8070404 |doi=
*cite journal | author=Wicks IP, Lapsys NM, Baker E, "et al." |title=Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2. |journal=Genomics |volume=19 |issue= 1 |pages= 38–41 |year= 1994 |pmid= 8188238 |doi= 10.1006/geno.1994.1009
*cite journal | author=Cerretti DP, Vanden Bos T, Nelson N, "et al." |title=Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. |journal=Mol. Immunol. |volume=32 |issue= 16 |pages= 1197–205 |year= 1996 |pmid= 8559144 |doi=
*cite journal | author=Lackmann M, Mann RJ, Kravets L, "et al." |title=Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16521–30 |year= 1997 |pmid= 9195962 |doi=
*cite journal | author=Kozlosky CJ, VandenBos T, Park L, "et al." |title=LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. |journal=Cytokine |volume=9 |issue= 8 |pages= 540–9 |year= 1997 |pmid= 9245480 |doi= 10.1006/cyto.1997.0199
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Lackmann M, Oates AC, Dottori M, "et al." |title=Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20228–37 |year= 1998 |pmid= 9685371 |doi=
*cite journal | author=Ciossek T, Monschau B, Kremoser C, "et al." |title=Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. |journal=Eur. J. Neurosci. |volume=10 |issue= 5 |pages= 1574–80 |year= 1998 |pmid= 9751130 |doi=

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