S100A12

S100 calcium binding protein A12, also known as S100A12, is a human gene.cite web | title = Entrez Gene: S100A12 S100 calcium binding protein A12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6283| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.cite web | title = Entrez Gene: S100A12 S100 calcium binding protein A12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6283| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Roth J, Vogl T, Sorg C, Sunderkötter C |title=Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. |journal=Trends Immunol. |volume=24 |issue= 4 |pages= 155–8 |year= 2004 |pmid= 12697438 |doi=
*cite journal | author=Guignard F, Mauel J, Markert M |title=Identification and characterization of a novel human neutrophil protein related to the S100 family. |journal=Biochem. J. |volume=309 ( Pt 2) |issue= |pages= 395–401 |year= 1995 |pmid= 7626002 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Yamamura T, Hitomi J, Nagasaki K, "et al." |title=Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping. |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 2 |pages= 356–60 |year= 1996 |pmid= 8619860 |doi=
*cite journal | author=Marti T, Erttmann KD, Gallin MY |title=Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin. |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 2 |pages= 454–8 |year= 1996 |pmid= 8619876 |doi= 10.1006/bbrc.1996.0616
*cite journal | author=Ilg EC, Troxler H, Bürgisser DM, "et al." |title=Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 146–50 |year= 1996 |pmid= 8769108 |doi= 10.1006/bbrc.1996.1144
*cite journal | author=Wicki R, Marenholz I, Mischke D, "et al." |title=Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21. |journal=Cell Calcium |volume=20 |issue= 6 |pages= 459–64 |year= 1997 |pmid= 8985590 |doi=
*cite journal | author=Hofmann MA, Drury S, Fu C, "et al." |title=RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. |journal=Cell |volume=97 |issue= 7 |pages= 889–901 |year= 1999 |pmid= 10399917 |doi=
*cite journal | author=Moroz OV, Antson AA, Dodson GG, "et al." |title=Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=56 |issue= Pt 2 |pages= 189–91 |year= 2000 |pmid= 10666601 |doi=
*cite journal | author=Moroz OV, Antson AA, Murshudov GN, "et al." |title=The three-dimensional structure of human S100A12. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 1 |pages= 20–9 |year= 2001 |pmid= 11134923 |doi=
*cite journal | author=Cole AM, Kim YH, Tahk S, "et al." |title=Calcitermin, a novel antimicrobial peptide isolated from human airway secretions. |journal=FEBS Lett. |volume=504 |issue= 1-2 |pages= 5–10 |year= 2001 |pmid= 11522286 |doi=
*cite journal | author=Moroz OV, Antson AA, Dodson EJ, "et al." |title=The structure of S100A12 in a hexameric form and its proposed role in receptor signalling. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue= Pt 3 |pages= 407–13 |year= 2002 |pmid= 11856825 |doi=
*cite journal | author=Strauss GI, Edvinsson L, Larsen FS, "et al." |title=Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. |journal=Neuropeptides |volume=35 |issue= 3-4 |pages= 174–80 |year= 2002 |pmid= 11884208 |doi= 10.1054/npep.2001.0861
*cite journal | author=Maayan C, Becker Y, Gesundheit B, Girgis SI |title=Calcitonin gene related peptide in familial dysautonomia. |journal=Neuropeptides |volume=35 |issue= 3-4 |pages= 189–95 |year= 2002 |pmid= 11884210 |doi= 10.1054/npep.2001.0863
*cite journal | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848–52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200
*cite journal | author=Ryckman C, Robichaud GA, Roy J, "et al." |title=HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes. |journal=J. Immunol. |volume=169 |issue= 6 |pages= 3307–13 |year= 2002 |pmid= 12218151 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Foell D, Ichida F, Vogl T, "et al." |title=S100A12 (EN-RAGE) in monitoring Kawasaki disease. |journal=Lancet |volume=361 |issue= 9365 |pages= 1270–2 |year= 2003 |pmid= 12699958 |doi=
*cite journal | author=Foell D, Kucharzik T, Kraft M, "et al." |title=Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease. |journal=Gut |volume=52 |issue= 6 |pages= 847–53 |year= 2003 |pmid= 12740341 |doi=

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