FAP (gene)

Fibroblast activation protein, alpha, also known as FAP, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.cite web | title = Entrez Gene: FAP fibroblast activation protein, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2191| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rettig WJ, Su SL, Fortunato SR, "et al." |title=Fibroblast activation protein: purification, epitope mapping and induction by growth factors. |journal=Int. J. Cancer |volume=58 |issue= 3 |pages= 385–92 |year= 1994 |pmid= 7519584 |doi=10.1002/ijc.2910580314
*cite journal | author=Mathew S, Scanlan MJ, Mohan Raj BK, "et al." |title=The gene for fibroblast activation protein alpha (FAP), a putative cell surface-bound serine protease expressed in cancer stroma and wound healing, maps to chromosome band 2q23. |journal=Genomics |volume=25 |issue= 1 |pages= 335–7 |year= 1995 |pmid= 7774951 |doi=10.1016/0888-7543(95)80157-H
*cite journal | author=Scanlan MJ, Raj BK, Calvo B, "et al." |title=Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 12 |pages= 5657–61 |year= 1994 |pmid= 7911242 |doi=10.1073/pnas.91.12.5657
*cite journal | author=Piñeiro-Sánchez ML, Goldstein LA, Dodt J, "et al." |title=Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 7595–601 |year= 1997 |pmid= 9065413 |doi=10.1074/jbc.272.12.7595
*cite journal | author=Goldstein LA, Ghersi G, Piñeiro-Sánchez ML, "et al." |title=Molecular cloning of seprase: a serine integral membrane protease from human melanoma. |journal=Biochim. Biophys. Acta |volume=1361 |issue= 1 |pages= 11–9 |year= 1997 |pmid= 9247085 |doi=
*cite journal | author=Goldstein LA, Chen WT |title=Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2554–9 |year= 2000 |pmid= 10644713 |doi=10.1074/jbc.275.4.2554
*cite journal | author=Ghersi G, Dong H, Goldstein LA, "et al." |title=Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29231–41 |year= 2002 |pmid= 12023964 |doi= 10.1074/jbc.M202770200
*cite journal | author=Levy MT, McCaughan GW, Marinos G, Gorrell MD |title=Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection. |journal=Liver |volume=22 |issue= 2 |pages= 93–101 |year= 2002 |pmid= 12028401 |doi=10.1034/j.1600-0676.2002.01503.x
*cite journal | author=Artym VV, Kindzelskii AL, Chen WT, Petty HR |title=Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton. |journal=Carcinogenesis |volume=23 |issue= 10 |pages= 1593–601 |year= 2002 |pmid= 12376466 |doi=10.1093/carcin/23.10.1593
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gorrell MD, Wang XM, Levy MT, "et al." |title=Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection. |journal=Adv. Exp. Med. Biol. |volume=524 |issue= |pages= 235–43 |year= 2003 |pmid= 12675244 |doi=10.1007/0-306-47920-6_28
*cite journal | author=Jin X, Iwasa S, Okada K, "et al." |title=Expression patterns of seprase, a membrane serine protease, in cervical carcinoma and cervical intraepithelial neoplasm. |journal=Anticancer Res. |volume=23 |issue= 4 |pages= 3195–8 |year= 2003 |pmid= 12926053 |doi=
*cite journal | author=Iwasa S, Jin X, Okada K, "et al." |title=Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer. |journal=Cancer Lett. |volume=199 |issue= 1 |pages= 91–8 |year= 2003 |pmid= 12963128 |doi=10.1016/S0304-3835(03)00315-X
*cite journal | author=Goodman JD, Rozypal TL, Kelly T |title=Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells. |journal=Clin. Exp. Metastasis |volume=20 |issue= 5 |pages= 459–70 |year= 2003 |pmid= 14524536 |doi=10.1023/A:1025493605850
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Okada K, Chen WT, Iwasa S, "et al." |title=Seprase, a membrane-type serine protease, has different expression patterns in intestinal- and diffuse-type gastric cancer. |journal=Oncology |volume=65 |issue= 4 |pages= 363–70 |year= 2004 |pmid= 14707457 |doi= 10.1159/000074650
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Cheng JD, Valianou M, Canutescu AA, "et al." |title=Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth. |journal=Mol. Cancer Ther. |volume=4 |issue= 3 |pages= 351–60 |year= 2005 |pmid= 15767544 |doi= 10.1158/1535-7163.MCT-04-0269 | doi_brokendate=2008-10-03
*cite journal | author=Aertgeerts K, Levin I, Shi L, "et al." |title=Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19441–4 |year= 2005 |pmid= 15809306 |doi= 10.1074/jbc.C500092200
*cite journal | author=Fassnacht M, Lee J, Milazzo C, "et al." |title=Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy. |journal=Clin. Cancer Res. |volume=11 |issue= 15 |pages= 5566–71 |year= 2006 |pmid= 16061874 |doi= 10.1158/1078-0432.CCR-05-0699

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