SRPK1

SFRS protein kinase 1, also known as SRPK1, is a human gene.cite web | title = Entrez Gene: SRPK1 SFRS protein kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6732| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.cite web | title = Entrez Gene: SRPK1 SFRS protein kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6732| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gui JF, Lane WS, Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678–82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0
*cite journal | author=Colwill K, Feng LL, Yeakley JM, "et al." |title=SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24569–75 |year= 1996 |pmid= 8798720 |doi=
*cite journal | author=Wang HY, Lin W, Dyck JA, "et al." |title=SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 737–50 |year= 1998 |pmid= 9472028 |doi=
*cite journal | author=Papoutsopoulou S, Nikolakaki E, Giannakouros T |title=SRPK1 and LBR protein kinases show identical substrate specificities. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 3 |pages= 602–7 |year= 1999 |pmid= 10049757 |doi= 10.1006/bbrc.1999.0249
*cite journal | author=Koizumi J, Okamoto Y, Onogi H, "et al." |title=The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11125–31 |year= 1999 |pmid= 10196197 |doi=
*cite journal | author=Wang HY, Arden KC, Bermingham JR, "et al." |title=Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. |journal=Genomics |volume=57 |issue= 2 |pages= 310–5 |year= 1999 |pmid= 10198174 |doi= 10.1006/geno.1999.5770
*cite journal | author=Paillard F |title=A novel soluble chimera for the treatment of familial hypercholesterolemia. |journal=Hum. Gene Ther. |volume=10 |issue= 7 |pages= 1093–4 |year= 1999 |pmid= 10340541 |doi= 10.1089/10430349950018085
*cite journal | author=Papoutsopoulou S, Nikolakaki E, Chalepakis G, "et al." |title=SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. |journal=Nucleic Acids Res. |volume=27 |issue= 14 |pages= 2972–80 |year= 1999 |pmid= 10390541 |doi=
*cite journal | author=Nikolakaki E, Kohen R, Hartmann AM, "et al." |title=Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40175–82 |year= 2001 |pmid= 11509566 |doi= 10.1074/jbc.M104755200
*cite journal | author=Daub H, Blencke S, Habenberger P, "et al." |title=Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. |journal=J. Virol. |volume=76 |issue= 16 |pages= 8124–37 |year= 2002 |pmid= 12134018 |doi=
*cite journal | author=Kamachi M, Le TM, Kim SJ, "et al." |title=Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. |journal=J. Exp. Med. |volume=196 |issue= 9 |pages= 1213–25 |year= 2003 |pmid= 12417631 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mylonis I, Giannakouros T |title=Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 650–6 |year= 2003 |pmid= 12565829 |doi=
*cite journal | author=Aubol BE, Chakrabarti S, Ngo J, "et al." |title=Processive phosphorylation of alternative splicing factor/splicing factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 22 |pages= 12601–6 |year= 2004 |pmid= 14555757 |doi= 10.1073/pnas.1635129100
*cite journal | author=Li J, Hawkins IC, Harvey CD, "et al." |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Mylonis I, Drosou V, Brancorsini S, "et al." |title=Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11626–31 |year= 2004 |pmid= 14701833 |doi= 10.1074/jbc.M311949200
*cite journal | author=Lee CG, Hague LK, Li H, Donnelly R |title=Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha. |journal=Cell Cycle |volume=3 |issue= 5 |pages= 638–47 |year= 2004 |pmid= 15034300 |doi=
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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