SFRS1

Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor), also known as SFRS1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: SFRS1 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6426| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zahler AM, Lane WS, Stolk JA, Roth MB |title=SR proteins: a conserved family of pre-mRNA splicing factors. |journal=Genes Dev. |volume=6 |issue= 5 |pages= 837–47 |year= 1992 |pmid= 1577277 |doi=
*cite journal | author=Mayeda A, Zahler AM, Krainer AR, Roth MB |title=Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1301–4 |year= 1992 |pmid= 1741384 |doi=
*cite journal | author=Krainer AR, Mayeda A, Kozak D, Binns G |title=Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. |journal=Cell |volume=66 |issue= 2 |pages= 383–94 |year= 1991 |pmid= 1830244 |doi=
*cite journal | author=Ge H, Zuo P, Manley JL |title=Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. |journal=Cell |volume=66 |issue= 2 |pages= 373–82 |year= 1991 |pmid= 1855257 |doi=
*cite journal | author=Zuo P, Manley JL |title=The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3363–7 |year= 1994 |pmid= 7512732 |doi=
*cite journal | author=Tacke R, Manley JL |title=The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. |journal=EMBO J. |volume=14 |issue= 14 |pages= 3540–51 |year= 1995 |pmid= 7543047 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kohtz JD, Jamison SF, Will CL, "et al." |title=Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. |journal=Nature |volume=368 |issue= 6467 |pages= 119–24 |year= 1994 |pmid= 8139654 |doi= 10.1038/368119a0
*cite journal | author=Luo Y, Yu H, Peterlin BM |title=Cellular protein modulates effects of human immunodeficiency virus type 1 Rev. |journal=J. Virol. |volume=68 |issue= 6 |pages= 3850–6 |year= 1994 |pmid= 8189522 |doi=
*cite journal | author=Gui JF, Lane WS, Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678–82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0
*cite journal | author=Zuo P, Manley JL |title=Functional domains of the human splicing factor ASF/SF2. |journal=EMBO J. |volume=12 |issue= 12 |pages= 4727–37 |year= 1993 |pmid= 8223481 |doi=
*cite journal | author=Wu JY, Maniatis T |title=Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. |journal=Cell |volume=75 |issue= 6 |pages= 1061–70 |year= 1994 |pmid= 8261509 |doi=
*cite journal | author=Bermingham JR, Arden KC, Naumova AK, "et al." |title=Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). |journal=Genomics |volume=29 |issue= 1 |pages= 70–9 |year= 1996 |pmid= 8530103 |doi= 10.1006/geno.1995.1216
*cite journal | author=Colwill K, Pawson T, Andrews B, "et al." |title=The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. |journal=EMBO J. |volume=15 |issue= 2 |pages= 265–75 |year= 1996 |pmid= 8617202 |doi=
*cite journal | author=Tange TO, Jensen TH, Kjems J |title=In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10066–72 |year= 1996 |pmid= 8626563 |doi=
*cite journal | author=Colwill K, Feng LL, Yeakley JM, "et al." |title=SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24569–75 |year= 1996 |pmid= 8798720 |doi=
*cite journal | author=Zhang WJ, Wu JY |title=Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5400–8 |year= 1996 |pmid= 8816452 |doi=
*cite journal | author=Powell DM, Amaral MC, Wu JY, "et al." |title=HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 3 |pages= 973–8 |year= 1997 |pmid= 9023367 |doi=
*cite journal | author=Tronchère H, Wang J, Fu XD |title=A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. |journal=Nature |volume=388 |issue= 6640 |pages= 397–400 |year= 1997 |pmid= 9237760 |doi= 10.1038/41137
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=

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