RAD52

RAD52

RAD52 homolog (S. cerevisiae), also known as RAD52, is a human gene.cite web | title = Entrez Gene: RAD52 RAD52 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5893| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.cite web | title = Entrez Gene: RAD52 RAD52 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5893| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Muris DF, Bezzubova O, Buerstedde JM, "et al." |title=Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination. |journal=Mutat. Res. |volume=315 |issue= 3 |pages= 295–305 |year= 1994 |pmid= 7526206 |doi=
*cite journal | author=Shen Z, Denison K, Lobb R, "et al." |title=The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. |journal=Genomics |volume=25 |issue= 1 |pages= 199–206 |year= 1995 |pmid= 7774919 |doi=
*cite journal | author=Park MS |title=Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15467–70 |year= 1995 |pmid= 7797537 |doi=
*cite journal | author=Shen Z, Pardington-Purtymun PE, Comeaux JC, "et al." |title=UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins. |journal=Genomics |volume=36 |issue= 2 |pages= 271–9 |year= 1997 |pmid= 8812453 |doi= 10.1006/geno.1996.0462
*cite journal | author=Shen Z, Pardington-Purtymun PE, Comeaux JC, "et al." |title=Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system. |journal=Genomics |volume=37 |issue= 2 |pages= 183–6 |year= 1997 |pmid= 8921390 |doi= 10.1006/geno.1996.0540
*cite journal | author=Chen G, Yuan SS, Liu W, "et al." |title=Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12748–52 |year= 1999 |pmid= 10212258 |doi=
*cite journal | author=Kito K, Wada H, Yeh ET, Kamitani T |title=Identification of novel isoforms of human RAD52. |journal=Biochim. Biophys. Acta |volume=1489 |issue= 2-3 |pages= 303–14 |year= 2000 |pmid= 10673031 |doi=
*cite journal | author=Stasiak AZ, Larquet E, Stasiak A, "et al." |title=The human Rad52 protein exists as a heptameric ring. |journal=Curr. Biol. |volume=10 |issue= 6 |pages= 337–40 |year= 2000 |pmid= 10744977 |doi=
*cite journal | author=Parsons CA, Baumann P, Van Dyck E, West SC |title=Precise binding of single-stranded DNA termini by human RAD52 protein. |journal=EMBO J. |volume=19 |issue= 15 |pages= 4175–81 |year= 2000 |pmid= 10921897 |doi= 10.1093/emboj/19.15.4175
*cite journal | author=Mer G, Bochkarev A, Gupta R, "et al." |title=Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. |journal=Cell |volume=103 |issue= 3 |pages= 449–56 |year= 2000 |pmid= 11081631 |doi=
*cite journal | author=Ranatunga W, Jackson D, Flowers II RA, Borgstahl GE |title=Human RAD52 protein has extreme thermal stability. |journal=Biochemistry |volume=40 |issue= 29 |pages= 8557–62 |year= 2001 |pmid= 11456495 |doi=
*cite journal | author=Van Dyck E, Stasiak AZ, Stasiak A, West SC |title=Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing. |journal=EMBO Rep. |volume=2 |issue= 10 |pages= 905–9 |year= 2002 |pmid= 11571269 |doi= 10.1093/embo-reports/kve201
*cite journal | author=Kim PM, Allen C, Wagener BM, "et al." |title=Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells. |journal=Nucleic Acids Res. |volume=29 |issue= 21 |pages= 4352–60 |year= 2001 |pmid= 11691922 |doi=
*cite journal | author=Yáñez RJ, Porter AC |title=Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line. |journal=Nucleic Acids Res. |volume=30 |issue= 3 |pages= 740–8 |year= 2002 |pmid= 11809887 |doi=
*cite journal | author=Jackson D, Dhar K, Wahl JK, "et al." |title=Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA. |journal=J. Mol. Biol. |volume=321 |issue= 1 |pages= 133–48 |year= 2002 |pmid= 12139939 |doi=
*cite journal | author=Kagawa W, Kurumizaka H, Ishitani R, "et al." |title=Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form. |journal=Mol. Cell |volume=10 |issue= 2 |pages= 359–71 |year= 2002 |pmid= 12191481 |doi=
*cite journal | author=Singleton MR, Wentzell LM, Liu Y, "et al." |title=Structure of the single-strand annealing domain of human RAD52 protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13492–7 |year= 2002 |pmid= 12370410 |doi= 10.1073/pnas.212449899
*cite journal | author=Liu J, Meng X, Shen Z |title=Association of human RAD52 protein with transcription factors. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 5 |pages= 1191–6 |year= 2002 |pmid= 12372413 |doi=
*cite journal | author=Han J, Hankinson SE, De Vivo I, "et al." |title=No association between a stop codon polymorphism in RAD52 and breast cancer risk. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=11 |issue= 10 Pt 1 |pages= 1138–9 |year= 2002 |pmid= 12376524 |doi=
*cite journal | author=Kitao H, Yuan ZM |title=Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48944–8 |year= 2003 |pmid= 12379650 |doi= 10.1074/jbc.M208151200

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