TOPBP1

Topoisomerase (DNA) II binding protein 1, also known as TOPBP1, is a human gene.cite web | title = Entrez Gene: TOPBP1 topoisomerase (DNA) II binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11073| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.cite web | title = Entrez Gene: TOPBP1 topoisomerase (DNA) II binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11073| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=Yamane K, Kawabata M, Tsuruo T |title=A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator. |journal=Eur. J. Biochem. |volume=250 |issue= 3 |pages= 794–9 |year= 1997 |pmid= 9461304 |doi=
*cite journal | author=Yamane K, Tsuruo T |title=Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA. |journal=Oncogene |volume=18 |issue= 37 |pages= 5194–203 |year= 1999 |pmid= 10498869 |doi= 10.1038/sj.onc.1202922
*cite journal | author=Mäkiniemi M, Hillukkala T, Tuusa J, "et al." |title=BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30399–406 |year= 2001 |pmid= 11395493 |doi= 10.1074/jbc.M102245200
*cite journal | author=Honda Y, Tojo M, Matsuzaki K, "et al." |title=Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3599–605 |year= 2002 |pmid= 11714696 |doi= 10.1074/jbc.M104347200
*cite journal | author=Yamane K, Wu X, Chen J |title=A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. |journal=Mol. Cell. Biol. |volume=22 |issue= 2 |pages= 555–66 |year= 2002 |pmid= 11756551 |doi=
*cite journal | author=Boner W, Taylor ER, Tsirimonaki E, "et al." |title=A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22297–303 |year= 2002 |pmid= 11934899 |doi= 10.1074/jbc.M202163200
*cite journal | author=Herold S, Wanzel M, Beuger V, "et al." |title=Negative regulation of the mammalian UV response by Myc through association with Miz-1. |journal=Mol. Cell |volume=10 |issue= 3 |pages= 509–21 |year= 2002 |pmid= 12408820 |doi=
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu K, Lin FT, Ruppert JM, Lin WC |title=Regulation of E2F1 by BRCT domain-containing protein TopBP1. |journal=Mol. Cell. Biol. |volume=23 |issue= 9 |pages= 3287–304 |year= 2003 |pmid= 12697828 |doi=
*cite journal | author=Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS |title=PML colocalizes with and stabilizes the DNA damage response protein TopBP1. |journal=Mol. Cell. Biol. |volume=23 |issue= 12 |pages= 4247–56 |year= 2003 |pmid= 12773567 |doi=
*cite journal | author=Yamane K, Chen J, Kinsella TJ |title=Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3049–53 |year= 2003 |pmid= 12810625 |doi=
*cite journal | author=Greer DA, Besley BD, Kennedy KB, Davey S |title=hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation. |journal=Cancer Res. |volume=63 |issue= 16 |pages= 4829–35 |year= 2003 |pmid= 12941802 |doi=
*cite journal | author=Manke IA, Lowery DM, Nguyen A, Yaffe MB |title=BRCT repeats as phosphopeptide-binding modules involved in protein targeting. |journal=Science |volume=302 |issue= 5645 |pages= 636–9 |year= 2003 |pmid= 14576432 |doi= 10.1126/science.1088877
*cite journal | author=Yu X, Chini CC, He M, "et al." |title=The BRCT domain is a phospho-protein binding domain. |journal=Science |volume=302 |issue= 5645 |pages= 639–42 |year= 2003 |pmid= 14576433 |doi= 10.1126/science.1088753
*cite journal | author=Liu K, Luo Y, Lin FT, Lin WC |title=TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. |journal=Genes Dev. |volume=18 |issue= 6 |pages= 673–86 |year= 2004 |pmid= 15075294 |doi= 10.1101/gad.1180204
*cite journal | author=Reini K, Uitto L, Perera D, "et al." |title=TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis. |journal=Chromosoma |volume=112 |issue= 7 |pages= 323–30 |year= 2005 |pmid= 15138768 |doi= 10.1007/s00412-004-0277-5
*cite journal | author=Hassel S, Eichner A, Yakymovych M, "et al." |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770
*cite journal | author=Yoshida K, Inoue I |title=Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. |journal=Oncogene |volume=23 |issue= 37 |pages= 6250–60 |year= 2004 |pmid= 15195143 |doi= 10.1038/sj.onc.1207829

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