TCF20

TCF20

Transcription factor 20 (AR1), also known as TCF20, is a human gene.cite web | title = Entrez Gene: TCF20 transcription factor 20 (AR1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6942| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene binds a platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (stromelysin 1) promoter. The protein localizes to the nucleus and displays DNA-binding and transactivation activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: TCF20 transcription factor 20 (AR1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6942| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sanz L, Moscat J, Diaz-Meco MT |title=Molecular characterization of a novel transcription factor that controls stromelysin expression. |journal=Mol. Cell. Biol. |volume=15 |issue= 6 |pages= 3164–70 |year= 1995 |pmid= 7760812 |doi=
*cite journal | author=Kirstein M, Sanz L, Quiñones S, "et al." |title=Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18231–6 |year= 1996 |pmid= 8663478 |doi=
*cite journal | author=Ohara O, Nagase T, Ishikawa K, "et al." |title=Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. |journal=DNA Res. |volume=4 |issue= 1 |pages= 53–9 |year= 1997 |pmid= 9179496 |doi=
*cite journal | author=Rajadhyaksha A, Rivière M, Van Vooren P, "et al." |title=Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 176–7 |year= 1998 |pmid= 9730594 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Lyngsø C, Bouteiller G, Damgaard CK, "et al." |title=Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26144–9 |year= 2000 |pmid= 10849425 |doi= 10.1074/jbc.M003405200
*cite journal | author=Rekdal C, Sjøttem E, Johansen T |title=The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40288–300 |year= 2001 |pmid= 10995766 |doi= 10.1074/jbc.M006978200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Gburcik V, Bot N, Maggiolini M, Picard D |title=SPBP is a phosphoserine-specific repressor of estrogen receptor alpha. |journal=Mol. Cell. Biol. |volume=25 |issue= 9 |pages= 3421–30 |year= 2005 |pmid= 15831449 |doi= 10.1128/MCB.25.9.3421-3430.2005
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Sjøttem E, Rekdal C, Svineng G, "et al." |title=The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. |journal=Nucleic Acids Res. |volume=35 |issue= 19 |pages= 6648–62 |year= 2007 |pmid= 17913746 |doi= 10.1093/nar/gkm739

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”