RANGAP1

RANGAP1

Ran GTPase activating protein 1, also known as RANGAP1, is a human gene.cite web | title = Entrez Gene: RANGAP1 Ran GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5905| accessdate = ]

PBB_Summary
section_title =
summary_text = RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.cite web | title = Entrez Gene: RANGAP1 Ran GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5905| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Becker J, Melchior F, Gerke V, "et al." |title=RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 11860–5 |year= 1995 |pmid= 7744835 |doi=
*cite journal | author=Bischoff FR, Krebber H, Kempf T, "et al." |title=Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1749–53 |year= 1995 |pmid= 7878053 |doi=
*cite journal | author=Bischoff FR, Klebe C, Kretschmer J, "et al." |title=RanGAP1 induces GTPase activity of nuclear Ras-related Ran. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2587–91 |year= 1994 |pmid= 8146159 |doi=
*cite journal | author=Krebber H, Ponstingl H |title=Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. |journal=Gene |volume=180 |issue= 1-2 |pages= 7–11 |year= 1997 |pmid= 8973340 |doi=
*cite journal | author=Matunis MJ, Coutavas E, Blobel G |title=A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. |journal=J. Cell Biol. |volume=135 |issue= 6 Pt 1 |pages= 1457–70 |year= 1997 |pmid= 8978815 |doi=
*cite journal | author=Mahajan R, Delphin C, Guan T, "et al." |title=A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. |journal=Cell |volume=88 |issue= 1 |pages= 97–107 |year= 1997 |pmid= 9019411 |doi=
*cite journal | author=Görlich D, Dabrowski M, Bischoff FR, "et al." |title=A novel class of RanGTP binding proteins. |journal=J. Cell Biol. |volume=138 |issue= 1 |pages= 65–80 |year= 1997 |pmid= 9214382 |doi=
*cite journal | author=Scheffzek K, Ahmadian MR, Kabsch W, "et al." |title=The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. |journal=Science |volume=277 |issue= 5324 |pages= 333–8 |year= 1998 |pmid= 9219684 |doi=
*cite journal | author=Mahajan R, Gerace L, Melchior F |title=Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association. |journal=J. Cell Biol. |volume=140 |issue= 2 |pages= 259–70 |year= 1998 |pmid= 9442102 |doi=
*cite journal | author=Kamitani T, Kito K, Nguyen HP, "et al." |title=Characterization of a second member of the sentrin family of ubiquitin-like proteins. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11349–53 |year= 1998 |pmid= 9556629 |doi=
*cite journal | author=Okuma T, Honda R, Ichikawa G, "et al." |title=In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 3 |pages= 693–8 |year= 1999 |pmid= 9920803 |doi= 10.1006/bbrc.1998.9995
*cite journal | author=Hillig RC, Renault L, Vetter IR, "et al." |title=The crystal structure of rna1p: a new fold for a GTPase-activating protein. |journal=Mol. Cell |volume=3 |issue= 6 |pages= 781–91 |year= 1999 |pmid= 10394366 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Nagase T, Nakayama M, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=
*cite journal | author=Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD |title=Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. |journal=Cell |volume=108 |issue= 3 |pages= 345–56 |year= 2002 |pmid= 11853669 |doi=
*cite journal | author=Joseph J, Tan SH, Karpova TS, "et al." |title=SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 595–602 |year= 2002 |pmid= 11854305 |doi= 10.1083/jcb.200110109
*cite journal | author=Zhang H, Saitoh H, Matunis MJ |title=Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6498–508 |year= 2002 |pmid= 12192048 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Macauley MS, Errington WJ, Okon M, "et al." |title=Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49131–7 |year= 2005 |pmid= 15355965 |doi= 10.1074/jbc.M408705200

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