Ephrin A1

Ephrin-A1, also known as EFNA1, is a human gene.cite web | title = Entrez Gene: EFNA1 ephrin-A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1942| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.cite web | title = Entrez Gene: EFNA1 ephrin-A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1942| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pandey A, Lindberg RA, Dixit VM |title=Cell signalling. Receptor orphans find a family. |journal=Curr. Biol. |volume=5 |issue= 9 |pages= 986–9 |year= 1996 |pmid= 8542290 |doi=
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Holzman LB, Marks RM, Dixit VM |title=A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. |journal=Mol. Cell. Biol. |volume=10 |issue= 11 |pages= 5830–8 |year= 1990 |pmid= 2233719 |doi=
*cite journal | author=Mahadevan D, Thanki N, Singh J, "et al." |title=Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta ARK1 and their differential binding to G beta gamma subunits. |journal=Biochemistry |volume=34 |issue= 28 |pages= 9111–7 |year= 1995 |pmid= 7619809 |doi=
*cite journal | author=Kozlosky CJ, Maraskovsky E, McGrew JT, "et al." |title=Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. |journal=Oncogene |volume=10 |issue= 2 |pages= 299–306 |year= 1995 |pmid= 7838529 |doi=
*cite journal | author=Davis S, Gale NW, Aldrich TH, "et al." |title=Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. |journal=Science |volume=266 |issue= 5186 |pages= 816–9 |year= 1994 |pmid= 7973638 |doi=
*cite journal | author=Beckmann MP, Cerretti DP, Baum P, "et al." |title=Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3757–62 |year= 1994 |pmid= 8070404 |doi=
*cite journal | author=Cerretti DP, Lyman SD, Kozlosky CJ, "et al." |title=The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. |journal=Genomics |volume=33 |issue= 2 |pages= 277–82 |year= 1997 |pmid= 8660976 |doi= 10.1006/geno.1996.0192
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Nagel W, Schilcher P, Zeitlmann L, Kolanus W |title=The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function. |journal=Mol. Biol. Cell |volume=9 |issue= 8 |pages= 1981–94 |year= 1998 |pmid= 9693361 |doi=

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