EFNB2

Ephrin-B2, also known as EFNB2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.cite web | title = Entrez Gene: EFNB2 ephrin-B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1948| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Bennett BD, Zeigler FC, Gu Q, "et al." |title=Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 1866–70 |year= 1995 |pmid= 7534404 |doi=
*cite journal | author=Bonaldo MF, Yu MT, Jelenc P, "et al." |title=Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13. |journal=Hum. Mol. Genet. |volume=3 |issue= 9 |pages= 1663–73 |year= 1995 |pmid= 7833926 |doi=
*cite journal | author=Cerretti DP, Vanden Bos T, Nelson N, "et al." |title=Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. |journal=Mol. Immunol. |volume=32 |issue= 16 |pages= 1197–205 |year= 1996 |pmid= 8559144 |doi=
*cite journal | author=Cerretti DP, Lyman SD, Kozlosky CJ, "et al." |title=The genes encoding the eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3. |journal=Genomics |volume=33 |issue= 2 |pages= 277–82 |year= 1997 |pmid= 8660976 |doi= 10.1006/geno.1996.0192
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author=Holland SJ, Gale NW, Mbamalu G, "et al." |title=Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. |journal=Nature |volume=383 |issue= 6602 |pages= 722–5 |year= 1996 |pmid= 8878483 |doi= 10.1038/383722a0
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Vogt T, Stolz W, Welsh J, "et al." |title=Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. |journal=Clin. Cancer Res. |volume=4 |issue= 3 |pages= 791–7 |year= 1998 |pmid= 9533549 |doi=
*cite journal | author=Wang HU, Chen ZF, Anderson DJ |title=Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. |journal=Cell |volume=93 |issue= 5 |pages= 741–53 |year= 1998 |pmid= 9630219 |doi=
*cite journal | author=Nikolova Z, Djonov V, Zuercher G, "et al." |title=Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis. |journal=J. Cell. Sci. |volume=111 ( Pt 18) |issue= |pages= 2741–51 |year= 1998 |pmid= 9718367 |doi=
*cite journal | author=Torres R, Firestein BL, Dong H, "et al." |title=PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. |journal=Neuron |volume=21 |issue= 6 |pages= 1453–63 |year= 1999 |pmid= 9883737 |doi=
*cite journal | author=Lin D, Gish GD, Songyang Z, Pawson T |title=The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3726–33 |year= 1999 |pmid= 9920925 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes