S100A1

S100 calcium binding protein A1, also known as S100A1, is a human gene.cite web | title = Entrez Gene: S100A1 S100 calcium binding protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6271| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.cite web | title = Entrez Gene: S100A1 S100 calcium binding protein A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6271| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zimmer DB, Cornwall EH, Landar A, Song W |title=The S100 protein family: history, function, and expression. |journal=Brain Res. Bull. |volume=37 |issue= 4 |pages= 417–29 |year= 1995 |pmid= 7620916 |doi=
*cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi=
*cite journal | author=Garbuglia M, Verzini M, Sorci G, "et al." |title=The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. |journal=Braz. J. Med. Biol. Res. |volume=32 |issue= 10 |pages= 1177–85 |year= 2000 |pmid= 10510252 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Erne P, Heizmann CW |title=S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. |journal=Biochemistry |volume=31 |issue= 42 |pages= 10258–64 |year= 1992 |pmid= 1384693 |doi=
*cite journal | author=Morii K, Tanaka R, Takahashi Y, "et al." |title=Structure and chromosome assignment of human S100 alpha and beta subunit genes. |journal=Biochem. Biophys. Res. Commun. |volume=175 |issue= 1 |pages= 185–91 |year= 1991 |pmid= 1998503 |doi=
*cite journal | author=Baudier J, Glasser N, Gerard D |title=Ions binding to S100 proteins. I. Calcium- and zinc-binding properties of bovine brain S100 alpha alpha, S100a (alpha beta), and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b protein. |journal=J. Biol. Chem. |volume=261 |issue= 18 |pages= 8192–203 |year= 1986 |pmid= 3722149 |doi=
*cite journal | author=Kato K, Kimura S |title=S100ao (alpha alpha) protein is mainly located in the heart and striated muscles. |journal=Biochim. Biophys. Acta |volume=842 |issue= 2-3 |pages= 146–50 |year= 1985 |pmid= 4052452 |doi=
*cite journal | author=Schäfer BW, Wicki R, Engelkamp D, "et al." |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=
*cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, "et al." |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547–51 |year= 1993 |pmid= 8341667 |doi=
*cite journal | author=Garbuglia M, Verzini M, Giambanco I, "et al." |title=Effects of calcium-binding proteins (S-100a(o), S-100a, S-100b) on desmin assembly in vitro. |journal=FASEB J. |volume=10 |issue= 2 |pages= 317–24 |year= 1996 |pmid= 8641565 |doi=
*cite journal | author=Landar A, Caddell G, Chessher J, Zimmer DB |title=Identification of an S100A1/S100B target protein: phosphoglucomutase. |journal=Cell Calcium |volume=20 |issue= 3 |pages= 279–85 |year= 1997 |pmid= 8894274 |doi=
*cite journal | author=Remppis A, Greten T, Schäfer BW, "et al." |title=Altered expression of the Ca(2+)-binding protein S100A1 in human cardiomyopathy. |journal=Biochim. Biophys. Acta |volume=1313 |issue= 3 |pages= 253–7 |year= 1996 |pmid= 8898862 |doi=
*cite journal | author=Treves S, Scutari E, Robert M, "et al." |title=Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. |journal=Biochemistry |volume=36 |issue= 38 |pages= 11496–503 |year= 1997 |pmid= 9298970 |doi= 10.1021/bi970160w
*cite journal | author=Groves P, Finn BE, Kuźnicki J, Forsén S |title=A model for target protein binding to calcium-activated S100 dimers. |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 175–9 |year= 1998 |pmid= 9468301 |doi=
*cite journal | author=Mandinova A, Atar D, Schäfer BW, "et al." |title=Distinct subcellular localization of calcium binding S100 proteins in human smooth muscle cells and their relocation in response to rises in intracellular calcium. |journal=J. Cell. Sci. |volume=111 ( Pt 14) |issue= |pages= 2043–54 |year= 1998 |pmid= 9645951 |doi=
*cite journal | author=Osterloh D, Ivanenkov VV, Gerke V |title=Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization. |journal=Cell Calcium |volume=24 |issue= 2 |pages= 137–51 |year= 1999 |pmid= 9803314 |doi=
*cite journal | author=Garbuglia M, Verzini M, Donato R |title=Annexin VI binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments. |journal=Cell Calcium |volume=24 |issue= 3 |pages= 177–91 |year= 1999 |pmid= 9883272 |doi=
*cite journal | author=Ridinger K, Ilg EC, Niggli FK, "et al." |title=Clustered organization of S100 genes in human and mouse. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 254–63 |year= 1999 |pmid= 9920416 |doi=

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