TNFAIP3

Tumor necrosis factor, alpha-induced protein 3, also known as TNFAIP3, is a human gene.cite web | title = Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7128| accessdate = ]

PBB_Summary
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summary_text = This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.cite web | title = Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7128| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Opipari AW, Boguski MS, Dixit VM |title=The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. |journal=J. Biol. Chem. |volume=265 |issue= 25 |pages= 14705–8 |year= 1990 |pmid= 2118515 |doi=
*cite journal | author=Dixit VM, Green S, Sarma V, "et al." |title=Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2973–8 |year= 1990 |pmid= 2406243 |doi=
*cite journal | author=Cooper JT, Stroka DM, Brostjan C, "et al." |title=A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18068–73 |year= 1996 |pmid= 8663499 |doi=
*cite journal | author=Song HY, Rothe M, Goeddel DV |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6721–5 |year= 1996 |pmid= 8692885 |doi=
*cite journal | author=Vincenz C, Dixit VM |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20029–34 |year= 1996 |pmid= 8702721 |doi=
*cite journal | author=De Valck D, Heyninck K, Van Criekinge W, "et al." |title=A20, an inhibitor of cell death, self-associates by its zinc finger domain. |journal=FEBS Lett. |volume=384 |issue= 1 |pages= 61–4 |year= 1996 |pmid= 8797804 |doi=
*cite journal | author=De Valck D, Heyninck K, Van Criekinge W, "et al." |title=A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 2 |pages= 590–4 |year= 1997 |pmid= 9299557 |doi= 10.1006/bbrc.1997.7343
*cite journal | author=Eliopoulos AG, Blake SM, Floettmann JE, "et al." |title=Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1023–35 |year= 1999 |pmid= 9882303 |doi=
*cite journal | author=Heyninck K, Beyaert R |title=The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. |journal=FEBS Lett. |volume=442 |issue= 2-3 |pages= 147–50 |year= 1999 |pmid= 9928991 |doi=
*cite journal | author=Heyninck K, De Valck D, Vanden Berghe W, "et al." |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471–82 |year= 1999 |pmid= 10385526 |doi=
*cite journal | author=De Valck D, Jin DY, Heyninck K, "et al." |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. |journal=Oncogene |volume=18 |issue= 29 |pages= 4182–90 |year= 1999 |pmid= 10435631 |doi= 10.1038/sj.onc.1202787
*cite journal | author=Zhang SQ, Kovalenko A, Cantarella G, Wallach D |title=Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. |journal=Immunity |volume=12 |issue= 3 |pages= 301–11 |year= 2000 |pmid= 10755617 |doi=
*cite journal | author=Lee EG, Boone DL, Chai S, "et al." |title=Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. |journal=Science |volume=289 |issue= 5488 |pages= 2350–4 |year= 2000 |pmid= 11009421 |doi=
*cite journal | author=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93–7 |year= 2001 |pmid= 11389905 |doi=
*cite journal | author=Van Huffel S, Delaei F, Heyninck K, "et al." |title=Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30216–23 |year= 2001 |pmid= 11390377 |doi= 10.1074/jbc.M100048200
*cite journal | author=Evans PC, Taylor ER, Coadwell J, "et al." |title=Isolation and characterization of two novel A20-like proteins. |journal=Biochem. J. |volume=357 |issue= Pt 3 |pages= 617–23 |year= 2001 |pmid= 11463333 |doi=
*cite journal | author=Baltathakis I, Alcantara O, Boldt DH |title=Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling. |journal=J. Cell. Biochem. |volume=83 |issue= 2 |pages= 281–90 |year= 2001 |pmid= 11573245 |doi=
*cite journal | author=Zetoune FS, Murthy AR, Shao Z, "et al." |title=A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome. |journal=Cytokine |volume=15 |issue= 6 |pages= 282–98 |year= 2002 |pmid= 11594795 |doi= 10.1006/cyto.2001.0921
*cite journal | author=Wu WS, Xu ZX, Chang KS |title=The promyelocytic leukemia protein represses A20-mediated transcription. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31734–9 |year= 2002 |pmid= 12080044 |doi= 10.1074/jbc.M201648200
*cite journal | author=He KL, Ting AT |title=A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6034–45 |year= 2002 |pmid= 12167698 |doi=

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