SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, also known as SMARCA2, is a human gene.cite web | title = Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.cite web | title = Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aves SJ, Hindley J, Phear GA, Tongue N |title=A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains. |journal=Mol. Gen. Genet. |volume=248 |issue= 4 |pages= 491–8 |year= 1995 |pmid= 7565614 |doi=
*cite journal | author=Muchardt C, Yaniv M, Mattei MG |title=Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization. |journal=Mamm. Genome |volume=5 |issue= 4 |pages= 241–3 |year= 1994 |pmid= 8012116 |doi=
*cite journal | author=Chiba H, Muramatsu M, Nomoto A, Kato H |title=Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. |journal=Nucleic Acids Res. |volume=22 |issue= 10 |pages= 1815–20 |year= 1994 |pmid= 8208605 |doi=
*cite journal | author=Muchardt C, Yaniv M |title=A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. |journal=EMBO J. |volume=12 |issue= 11 |pages= 4279–90 |year= 1993 |pmid= 8223438 |doi=
*cite journal | author=Muchardt C, Reyes JC, Bourachot B, "et al." |title=The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3394–402 |year= 1996 |pmid= 8670841 |doi=
*cite journal | author=Wang W, Xue Y, Zhou S, "et al." |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117–30 |year= 1996 |pmid= 8804307 |doi=
*cite journal | author=Wang W, Côté J, Xue Y, "et al." |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370–82 |year= 1996 |pmid= 8895581 |doi=
*cite journal | author=Ichinose H, Garnier JM, Chambon P, Losson R |title=Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. |journal=Gene |volume=188 |issue= 1 |pages= 95–100 |year= 1997 |pmid= 9099865 |doi=
*cite journal | author=Cho H, Orphanides G, Sun X, "et al." |title=A human RNA polymerase II complex containing factors that modify chromatin structure. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5355–63 |year= 1998 |pmid= 9710619 |doi=
*cite journal | author=Thaete C, Brett D, Monaghan P, "et al." |title=Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 585–91 |year= 1999 |pmid= 10072425 |doi=
*cite journal | author=Phelan ML, Sif S, Narlikar GJ, Kingston RE |title=Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. |journal=Mol. Cell |volume=3 |issue= 2 |pages= 247–53 |year= 1999 |pmid= 10078207 |doi=
*cite journal | author=Lee DW, Zhang K, Ning ZQ, "et al." |title=Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. |journal=Cancer Res. |volume=60 |issue= 13 |pages= 3612–22 |year= 2000 |pmid= 10910076 |doi=
*cite journal | author=Phelan ML, Schnitzler GR, Kingston RE |title=Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6380–9 |year= 2000 |pmid= 10938115 |doi=
*cite journal | author=Xue Y, Canman JC, Lee CS, "et al." |title=The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13015–20 |year= 2001 |pmid= 11078522 |doi= 10.1073/pnas.240208597
*cite journal | author=Machida Y, Murai K, Miyake K, Iijima S |title=Expression of chromatin remodeling factors during neural differentiation. |journal=J. Biochem. |volume=129 |issue= 1 |pages= 43–9 |year= 2001 |pmid= 11134956 |doi=
*cite journal | author=de la Serna IL, Carlson KA, Imbalzano AN |title=Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation. |journal=Nat. Genet. |volume=27 |issue= 2 |pages= 187–90 |year= 2001 |pmid= 11175787 |doi= 10.1038/84826
*cite journal | author=Ruhf ML, Braun A, Papoulas O, "et al." |title=The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes. |journal=Development |volume=128 |issue= 8 |pages= 1429–41 |year= 2001 |pmid= 11262242 |doi=
*cite journal | author=Strobeck MW, Reisman DN, Gunawardena RW, "et al." |title=Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4782–9 |year= 2002 |pmid= 11719516 |doi= 10.1074/jbc.M109532200
*cite journal | author=Kato H, Tjernberg A, Zhang W, "et al." |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498–505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200
*cite journal | author=Mizutani T, Ito T, Nishina M, "et al." |title=Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15859–64 |year= 2002 |pmid= 11850427 |doi= 10.1074/jbc.M112421200

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