PRKAA1

Protein kinase, AMP-activated, alpha 1 catalytic subunit, also known as PRKAA1, is a human gene.cite web | title = Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5562| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5562| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Munday MR, Campbell DG, Carling D, Hardie DG |title=Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. |journal=Eur. J. Biochem. |volume=175 |issue= 2 |pages= 331–8 |year= 1988 |pmid= 2900138 |doi=
*cite journal | author=Stapleton D, Mitchelhill KI, Gao G, "et al." |title=Mammalian AMP-activated protein kinase subfamily. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 611–4 |year= 1996 |pmid= 8557660 |doi=
*cite journal | author=Woods A, Cheung PC, Smith FC, "et al." |title=Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10282–90 |year= 1996 |pmid= 8626596 |doi=
*cite journal | author=Hawley SA, Davison M, Woods A, "et al." |title=Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27879–87 |year= 1996 |pmid= 8910387 |doi=
*cite journal | author=Stapleton D, Woollatt E, Mitchelhill KI, "et al." |title=AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 452–6 |year= 1997 |pmid= 9224708 |doi=
*cite journal | author=Velasco G, Gómez del Pulgar T, Carling D, Guzmán M |title=Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. |journal=FEBS Lett. |volume=439 |issue= 3 |pages= 317–20 |year= 1998 |pmid= 9845345 |doi=
*cite journal | author=Crute BE, Seefeld K, Gamble J, "et al." |title=Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35347–54 |year= 1999 |pmid= 9857077 |doi=
*cite journal | author=da Silva Xavier G, Leclerc I, Salt IP, "et al." |title=Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4023–8 |year= 2000 |pmid= 10760274 |doi=
*cite journal | author=Hallows KR, Raghuram V, Kemp BE, "et al." |title=Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. |journal=J. Clin. Invest. |volume=105 |issue= 12 |pages= 1711–21 |year= 2000 |pmid= 10862786 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Chen ZP, McConell GK, Michell BJ, "et al." |title=AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=279 |issue= 5 |pages= E1202–6 |year= 2000 |pmid= 11052978 |doi=
*cite journal | author=Blázquez C, Geelen MJ, Velasco G, Guzmán M |title=The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes. |journal=FEBS Lett. |volume=489 |issue= 2-3 |pages= 149–53 |year= 2001 |pmid= 11165240 |doi=
*cite journal | author=Diggle TA, Subkhankulova T, Lilley KS, "et al." |title=Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity. |journal=Biochem. J. |volume=353 |issue= Pt 3 |pages= 621–6 |year= 2001 |pmid= 11171059 |doi=
*cite journal | author=Wang X, Li W, Williams M, "et al." |title=Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4370–9 |year= 2001 |pmid= 11500364 |doi= 10.1093/emboj/20.16.4370
*cite journal | author=Xi X, Han J, Zhang JZ |title=Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41029–34 |year= 2001 |pmid= 11546797 |doi= 10.1074/jbc.M102824200
*cite journal | author=Fryer LG, Foufelle F, Barnes K, "et al." |title=Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. |journal=Biochem. J. |volume=363 |issue= Pt 1 |pages= 167–74 |year= 2002 |pmid= 11903059 |doi=
*cite journal | author=Yang CS, Weiner H |title=Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. |journal=Arch. Biochem. Biophys. |volume=400 |issue= 1 |pages= 105–10 |year= 2002 |pmid= 11913976 |doi= 10.1006/abbi.2002.2778
*cite journal | author=Bolster DR, Crozier SJ, Kimball SR, Jefferson LS |title=AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 23977–80 |year= 2002 |pmid= 11997383 |doi= 10.1074/jbc.C200171200
*cite journal | author=Esumi H, Izuishi K, Kato K, "et al." |title=Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32791–8 |year= 2002 |pmid= 12091379 |doi= 10.1074/jbc.M112270200
*cite journal | author=Horman S, Browne G, Krause U, "et al." |title=Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. |journal=Curr. Biol. |volume=12 |issue= 16 |pages= 1419–23 |year= 2003 |pmid= 12194824 |doi=

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