PSMA6

Proteasome (prosome, macropain) subunit, alpha type, 6, also known as PSMA6, is a human gene.cite web | title = Entrez Gene: PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5687| accessdate = ]

PBB_Summary
section_title =
summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.cite web | title = Entrez Gene: PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5687| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801–47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101
*cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281–3 |year= 2003 |pmid= 12914693 |doi=
*cite journal | author=DeMartino GN, Orth K, McCullough ML, "et al." |title=The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. |journal=Biochim. Biophys. Acta |volume=1079 |issue= 1 |pages= 29–38 |year= 1991 |pmid= 1888762 |doi=
*cite journal | author=Bey F, Silva Pereira I, Coux O, "et al." |title=The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. |journal=Mol. Gen. Genet. |volume=237 |issue= 1-2 |pages= 193–205 |year= 1993 |pmid= 7681138 |doi=
*cite journal | author=Kristensen P, Johnsen AH, Uerkvitz W, "et al." |title=Human proteasome subunits from 2-dimensional gels identified by partial sequencing. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1785–9 |year= 1995 |pmid= 7811265 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Nederlof PM, Wang HR, Baumeister W |title=Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 26 |pages= 12060–4 |year= 1996 |pmid= 8618844 |doi=
*cite journal | author=Bureau JP, Olink-Coux M, Brouard N, "et al." |title=Characterization of prosomes in human lymphocyte subpopulations and their presence as surface antigens. |journal=Exp. Cell Res. |volume=231 |issue= 1 |pages= 50–60 |year= 1997 |pmid= 9056411 |doi= 10.1006/excr.1996.3453
*cite journal | author=Seeger M, Ferrell K, Frank R, Dubiel W |title=HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8145–8 |year= 1997 |pmid= 9079628 |doi=
*cite journal | author=Gerards WL, de Jong WW, Bloemendal H, Boelens W |title=The human proteasomal subunit HsC8 induces ring formation of other alpha-type subunits. |journal=J. Mol. Biol. |volume=275 |issue= 1 |pages= 113–21 |year= 1998 |pmid= 9451443 |doi= 10.1006/jmbi.1997.1429
*cite journal | author=Henry L, Baz A, Château MT, "et al." |title=Proteasome (prosome) subunit variations during the differentiation of myeloid U937 cells. |journal=Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology |volume=15 |issue= 3 |pages= 131–44 |year= 1998 |pmid= 9497851 |doi=
*cite journal | author=Madani N, Kabat D |title=An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. |journal=J. Virol. |volume=72 |issue= 12 |pages= 10251–5 |year= 1998 |pmid= 9811770 |doi=
*cite journal | author=Simon JH, Gaddis NC, Fouchier RA, Malim MH |title=Evidence for a newly discovered cellular anti-HIV-1 phenotype. |journal=Nat. Med. |volume=4 |issue= 12 |pages= 1397–400 |year= 1998 |pmid= 9846577 |doi= 10.1038/3987
*cite journal | author=Elenich LA, Nandi D, Kent AE, "et al." |title=The complete primary structure of mouse 20S proteasomes. |journal=Immunogenetics |volume=49 |issue= 10 |pages= 835–42 |year= 1999 |pmid= 10436176 |doi=
*cite journal | author=Mulder LC, Muesing MA |title=Degradation of HIV-1 integrase by the N-end rule pathway. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29749–53 |year= 2000 |pmid= 10893419 |doi= 10.1074/jbc.M004670200
*cite journal | author=Kleijnen MF, Shih AH, Zhou P, "et al." |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409–19 |year= 2000 |pmid= 10983987 |doi=
*cite journal | author=Feng Y, Longo DL, Ferris DK |title=Polo-like kinase interacts with proteasomes and regulates their activity. |journal=Cell Growth Differ. |volume=12 |issue= 1 |pages= 29–37 |year= 2001 |pmid= 11205743 |doi=
*cite journal | author=Engidawork E, Juranville JF, Fountoulakis M, "et al." |title=Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 117–30 |year= 2002 |pmid= 11771738 |doi=
*cite journal | author=Sjakste T, Sjakste N, Scherrer K |title=Exon/intron organisation of human proteasome PROS-27 K gene. |journal=DNA Seq. |volume=12 |issue= 4 |pages= 261–5 |year= 2002 |pmid= 11924531 |doi=

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