MDM4

Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse), also known as MDM4, is a human gene.cite web | title = Entrez Gene: MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4194| accessdate = ]

PBB_Summary
section_title =
summary_text = The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2cite web | title = Entrez Gene: MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4194| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG |title=ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1166–70 |year= 2006 |pmid= 16082221 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Shvarts A, Steegenga WT, Riteco N, "et al." |title=MDMX: a novel p53-binding protein with some functional properties of MDM2. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5349–57 |year= 1996 |pmid= 8895579 |doi=
*cite journal | author=Shvarts A, Bazuine M, Dekker P, "et al." |title=Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. |journal=Genomics |volume=43 |issue= 1 |pages= 34–42 |year= 1997 |pmid= 9226370 |doi= 10.1006/geno.1997.4775
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Tanimura S, Ohtsuka S, Mitsui K, "et al." |title=MDM2 interacts with MDMX through their RING finger domains. |journal=FEBS Lett. |volume=447 |issue= 1 |pages= 5–9 |year= 1999 |pmid= 10218570 |doi=
*cite journal | author=Ongkeko WM, Wang XQ, Siu WY, "et al." |title=MDM2 and MDMX bind and stabilize the p53-related protein p73. |journal=Curr. Biol. |volume=9 |issue= 15 |pages= 829–32 |year= 1999 |pmid= 10469568 |doi=
*cite journal | author=Sharp DA, Kratowicz SA, Sank MJ, George DL |title=Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38189–96 |year= 2000 |pmid= 10608892 |doi=
*cite journal | author=Jackson MW, Lindstrom MS, Berberich SJ |title=MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25336–41 |year= 2001 |pmid= 11297540 |doi= 10.1074/jbc.M010685200
*cite journal | author=Parant J, Chavez-Reyes A, Little NA, "et al." |title=Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. |journal=Nat. Genet. |volume=29 |issue= 1 |pages= 92–5 |year= 2001 |pmid= 11528400 |doi= 10.1038/ng714
*cite journal | author=Gentiletti F, Mancini F, D'Angelo M, "et al." |title=MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. |journal=Oncogene |volume=21 |issue= 6 |pages= 867–77 |year= 2002 |pmid= 11840332 |doi= 10.1038/sj.onc.1205137
*cite journal | author=Harris RA, Yang A, Stein RC, "et al." |title=Cluster analysis of an extensive human breast cancer cell line protein expression map database. |journal=Proteomics |volume=2 |issue= 2 |pages= 212–23 |year= 2002 |pmid= 11840567 |doi=
*cite journal | author=Gu J, Kawai H, Nie L, "et al." |title=Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19251–4 |year= 2002 |pmid= 11953423 |doi= 10.1074/jbc.C200150200
*cite journal | author=Migliorini D, Lazzerini Denchi E, Danovi D, "et al." |title=Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5527–38 |year= 2002 |pmid= 12101245 |doi=
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=
*cite journal | author=Sabbatini P, McCormick F |title=MDMX inhibits the p300/CBP-mediated acetylation of p53. |journal=DNA Cell Biol. |volume=21 |issue= 7 |pages= 519–25 |year= 2002 |pmid= 12162806 |doi= 10.1089/104454902320219077
*cite journal | author=Li C, Chen L, Chen J |title=DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7562–71 |year= 2002 |pmid= 12370303 |doi=
*cite journal | author=Badciong JC, Haas AL |title=MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49668–75 |year= 2003 |pmid= 12393902 |doi= 10.1074/jbc.M208593200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kadakia M, Brown TL, McGorry MM, Berberich SJ |title=MdmX inhibits Smad transactivation. |journal=Oncogene |volume=21 |issue= 57 |pages= 8776–85 |year= 2003 |pmid= 12483531 |doi= 10.1038/sj.onc.1205993

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes