PTTG1

Pituitary tumor-transforming 1, also known as PTTG1, is a human gene.cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = ]

PBB_Summary
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summary_text = The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.cite web | title = Entrez Gene: PTTG1 pituitary tumor-transforming 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9232| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yu R, Melmed S |title=Pituitary tumor transforming gene: an update. |journal=Frontiers of hormone research |volume=32 |issue= |pages= 175–85 |year= 2004 |pmid= 15281346 |doi=
*cite journal | author=Tfelt-Hansen J, Kanuparthi D, Chattopadhyay N |title=The emerging role of pituitary tumor transforming gene in tumorigenesis. |journal=Clinical medicine & research |volume=4 |issue= 2 |pages= 130–7 |year= 2006 |pmid= 16809406 |doi=
*cite journal | author=Domínguez A, Ramos-Morales F, Romero F, "et al." |title=hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. |journal=Oncogene |volume=17 |issue= 17 |pages= 2187–93 |year= 1998 |pmid= 9811450 |doi= 10.1038/sj.onc.1202140
*cite journal | author=Zhang X, Horwitz GA, Prezant TR, "et al." |title=Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 156–66 |year= 1999 |pmid= 9892021 |doi=
*cite journal | author=Pei L |title=Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 3151–8 |year= 1999 |pmid= 9915854 |doi=
*cite journal | author=Kakar SS |title=Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 93–5 |year= 1999 |pmid= 9925941 |doi=
*cite journal | author=Zhang X, Horwitz GA, Heaney AP, "et al." |title=Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 2 |pages= 761–7 |year= 1999 |pmid= 10022450 |doi=
*cite journal | author=Lee IA, Seong C, Choe IS |title=Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene. |journal=Biochem. Mol. Biol. Int. |volume=47 |issue= 5 |pages= 891–7 |year= 1999 |pmid= 10365261 |doi=
*cite journal | author=Kakar SS, Jennes L |title=Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 211–6 |year= 1999 |pmid= 10393434 |doi=
*cite journal | author=Zou H, McGarry TJ, Bernal T, Kirschner MW |title=Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. |journal=Science |volume=285 |issue= 5426 |pages= 418–22 |year= 1999 |pmid= 10411507 |doi=
*cite journal | author=Kakar SS |title=Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). |journal=Gene |volume=240 |issue= 2 |pages= 317–24 |year= 2000 |pmid= 10580151 |doi=
*cite journal | author=Ramos-Morales F, Domínguez A, Romero F, "et al." |title=Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product. |journal=Oncogene |volume=19 |issue= 3 |pages= 403–9 |year= 2000 |pmid= 10656688 |doi= 10.1038/sj.onc.1203320
*cite journal | author=Chien W, Pei L |title=A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. |journal=J. Biol. Chem. |volume=275 |issue= 25 |pages= 19422–7 |year= 2000 |pmid= 10781616 |doi= 10.1074/jbc.M910105199
*cite journal | author=Ishikawa H, Heaney AP, Yu R, "et al." |title=Human pituitary tumor-transforming gene induces angiogenesis. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 2 |pages= 867–74 |year= 2001 |pmid= 11158059 |doi=
*cite journal | author=Zur A, Brandeis M |title=Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. |journal=EMBO J. |volume=20 |issue= 4 |pages= 792–801 |year= 2001 |pmid= 11179223 |doi= 10.1093/emboj/20.4.792
*cite journal | author=Romero F, Multon MC, Ramos-Morales F, "et al." |title=Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. |journal=Nucleic Acids Res. |volume=29 |issue= 6 |pages= 1300–7 |year= 2001 |pmid= 11238996 |doi=
*cite journal | author=Jallepalli PV, Waizenegger IC, Bunz F, "et al." |title=Securin is required for chromosomal stability in human cells. |journal=Cell |volume=105 |issue= 4 |pages= 445–57 |year= 2001 |pmid= 11371342 |doi=
*cite journal | author=Hilioti Z, Chung YS, Mochizuki Y, "et al." |title=The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. |journal=Curr. Biol. |volume=11 |issue= 17 |pages= 1347–52 |year= 2001 |pmid= 11553328 |doi=
*cite journal | author=Waizenegger I, Giménez-Abián JF, Wernic D, Peters JM |title=Regulation of human separase by securin binding and autocleavage. |journal=Curr. Biol. |volume=12 |issue= 16 |pages= 1368–78 |year= 2003 |pmid= 12194817 |doi=
*cite journal | author=McCabe CJ, Boelaert K, Tannahill LA, "et al." |title=Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 9 |pages= 4238–44 |year= 2002 |pmid= 12213878 |doi=

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