- O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
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O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Identifiers EC number 2.4.1.222 CAS number 299203-70-6 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Search PMC articles PubMed articles In enzymology, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (EC 2.4.1.222) is an enzyme that catalyzes the chemical reaction in which a beta-D-GlcNAc residue is transferred from UDP-D-GlcNAc to the fucose residue of a fucosylated protein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J0A and 2J0B.
References
- Stanley P, Irvine KD, Haltiwanger RS, Vogt TF (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 (6794): 369–75. doi:10.1038/35019000. PMID 10935626.
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