MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, also known as MFNG, is a human gene.cite web | title = Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4242| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.cite web | title = Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4242| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Johnston SH, Rauskolb C, Wilson R, "et al." |title=A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. |journal=Development |volume=124 |issue= 11 |pages= 2245–54 |year= 1997 |pmid= 9187150 |doi=
*cite journal | author=Cohen B, Bashirullah A, Dagnino L, "et al." |title=Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. |journal=Nat. Genet. |volume=16 |issue= 3 |pages= 283–8 |year= 1997 |pmid= 9207795 |doi= 10.1038/ng0797-283
*cite journal | author=Egan S, Herbrick JA, Tsui LC, "et al." |title=Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. |journal=Genomics |volume=54 |issue= 3 |pages= 576–7 |year= 1999 |pmid= 9878264 |doi= 10.1006/geno.1998.5559
*cite journal | author=Moran JL, Johnston SH, Rauskolb C, "et al." |title=Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. |journal=Mamm. Genome |volume=10 |issue= 6 |pages= 535–41 |year= 1999 |pmid= 10341080 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Van Tine BA, Knops J, Shaw GM, May WA |title=Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH). |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 132–3 |year= 2000 |pmid= 10640833 |doi=
*cite journal | author=Moloney DJ, Panin VM, Johnston SH, "et al." |title=Fringe is a glycosyltransferase that modifies Notch. |journal=Nature |volume=406 |issue= 6794 |pages= 369–75 |year= 2000 |pmid= 10935626 |doi= 10.1038/35019000
*cite journal | author=Shimizu K, Chiba S, Saito T, "et al." |title=Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25753–8 |year= 2001 |pmid= 11346656 |doi= 10.1074/jbc.M103473200
*cite journal | author=Thélu J, Rossio P, Favier B |title=Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing. |journal=BMC Dermatol. |volume=2 |issue= |pages= 7 |year= 2003 |pmid= 11978185 |doi=
*cite journal | author=Panin VM, Shao L, Lei L, "et al." |title=Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29945–52 |year= 2002 |pmid= 12036964 |doi= 10.1074/jbc.M204445200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shao L, Moloney DJ, Haltiwanger R |title=Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7775–82 |year= 2003 |pmid= 12486116 |doi= 10.1074/jbc.M212221200
*cite journal | author=Veeraraghavalu K, Pett M, Kumar RV, "et al." |title=Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. |journal=J. Virol. |volume=78 |issue= 16 |pages= 8687–700 |year= 2004 |pmid= 15280477 |doi= 10.1128/JVI.78.16.8687-8700.2004
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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