Kanamycin kinase

In enzymology, a kanamycin kinase (EC number|2.7.1.95) is an enzyme that catalyzes the chemical reaction

:ATP + kanamycin $ightleftharpoons$ ADP + kanamycin 3'-phosphate

Thus, the two substrates of this enzyme are ATP and kanamycin, whereas its two products are ADP and kanamycin 3'-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1J7I, PDB link|1J7L, PDB link|1J7U, PDB link|1L8T, PDB link|1ND4, PDB link|2B0Q, and PDB link|2BKK.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|62213-36-9."

Gene Ontology (GO) codes