- Ceramide cholinephosphotransferase
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ceramide cholinephosphotransferase Identifiers EC number 2.7.8.3 CAS number 9026-14-6 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a ceramide cholinephosphotransferase (EC 2.7.8.3) is an enzyme that catalyzes the chemical reaction
- CDP-choline + N-acylsphingosine CMP + sphingomyelin
Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism.
References
- Kennedy EP (1962). "Phosphorylcholine-glyceride transferase". Methods Enzymol. 5: 484–486.
- Sribney M and Kennedy EP (1958). "The enzymatic synthesis of sphingomyelin". J. Biol. Chem. 233 (6): 1315–1322. PMID 13610834.
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