1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4-kinase
In enzymology, a 1-phosphatidylinositol 4-kinase (EC number|2.7.1.67) is an enzyme that catalyzes the chemical reaction
:ATP + 1-phosphatidyl-1D-myo-inositol ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase. Other names in common use include phosphatidylinositol kinase (phosphorylating), phosphatidylinositol 4-kinase, phosphatidylinositol kinase, type II phosphatidylinositol kinase, PI kinase, and PI 4-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.
tructural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2JU0.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|37205-54-2."
Gene Ontology (GO) codes
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2010.
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