Dolichyl-phosphate beta-glucosyltransferase

dolichyl-phosphate beta-glucosyltransferase
Identifiers
EC number	2.4.1.117
CAS number	71061-42-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) is an enzyme that catalyzes the chemical reaction

UDP-glucose + dolichyl phosphate $\rightleftharpoons$ UDP + dolichyl beta-D-glucosyl phosphate

Thus, the two substrates of this enzyme are UDP-glucose and dolichyl phosphate, whereas its two products are UDP and dolichyl beta-D-glucosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase. Other names in common use include polyprenyl phosphate:UDP-D-glucose glucosyltransferase, UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol phosphate glucosyltransferase, UDP-glucose:dolicholphosphoryl glucosyltransferase, UDP-glucose:dolichyl monophosphate glucosyltransferase, and UDP-glucose:dolichyl phosphate glucosyltransferase. This enzyme participates in n-glycan biosynthesis.

References

• Behrens NH, Leloir LF (1970). "Dolichol monophosphate glucose: an intermediate in glucose transfer in liver". Proc. Natl. Acad. Sci. U. S. A. 66 (1): 153–9. doi:10.1073/pnas.66.1.153. PMC 286101. PMID 5273893. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286101. 
• Herscovics A, Bugge B, Jeanloz RW (1977). "Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose". J. Biol. Chem. 252 (7): 2271–7. PMID 849929. 
• Villemez CL, Carlo PL (1979). "Properties of a soluble polyprenyl phosphate: UDP-D-glucose glucosyltransferase". J. Biol. Chem. 254 (11): 4814–9. PMID 438216. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.4.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Paola S. Timiras Elétrica Look at other dictionaries: Dolichyl — Dolichyl, related to Dolichol, is used in the names of: Dolichyl beta D glucosyl phosphate, a molecule involved in glycosylation Dolichyl diphosphate polyphosphate phosphotransferase (EC 2.7.4.20) Dolichyl diphosphooligosaccharide protein… …   Wikipedia Ceramide glucosyltransferase — (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucosylceramide. It is classified under EC 2.4.1.80. It is inhibited by miglustat. See also Glucosylceramide External links MeSH… …   Wikipedia DPM3 — Dolichyl phosphate mannosyltransferase polypeptide 3 Identifiers Symbols DPM3; CDG1O; MGC125904; MGC125905; MGC34275 External IDs …   Wikipedia DPM1 — Dolichyl phosphate mannosyltransferase polypeptide 1, catalytic subunit Identifiers Symbols DPM1; CDGIE; MPDS External IDs …   Wikipedia Glycogen debranching enzyme — Amylo alpha 1, 6 glucosidase, 4 alpha glucanotransferase Identifiers Symbols AGL; GDE External IDs …   Wikipedia Glycogen phosphorylase — Phosphorylase The crystal structure of the rabit muscle glycogen phosphorylase AMP complex. AMP allosteric site (yellow), phosporylated Ser14 (orange), glycogen binding site (blue), catalytic site (red).[1] …   Wikipedia Purine nucleoside phosphorylase — Not to be confused with polynucleotide phosphorylase. purine nucleoside phosphorylase Identifiers EC number 2.4.2.1 CAS number …   Wikipedia Poly ADP ribose polymerase — For the sound, see Parp (onomatopoeic). ADP ribose …   Wikipedia Oligosaccharyltransferase — or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14 sugar oligosaccharide from dolichol to nascent protein. It is a type of glycosyltransferase. The sugar Glc3Man9GlcNAc2 (where Glc=Glucose, Man=Mannose, and GlcNAc=N… …   Wikipedia Diphtheria toxin — Diphtheria toxin, C domain complex of diphtheria toxin and heparin binding epidermal growth factor Identifiers Symbol Diphtheria C Pfam …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”