Dolichyl-phosphate beta-D-mannosyltransferase

dolichyl-phosphate beta-D-mannosyltransferase
Identifiers
EC number	2.4.1.83
CAS number	62213-44-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) is an enzyme that catalyzes the chemical reaction

GDP-mannose + dolichyl phosphate $\rightleftharpoons$ GDP + dolichyl D-mannosyl phosphate

Thus, the two substrates of this enzyme are GDP-mannose and dolichyl phosphate, whereas its two products are GDP and dolichyl D-mannosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase. Other names in common use include GDP-Man:DolP mannosyltransferase, dolichyl mannosyl phosphate synthase, dolichyl-phospho-mannose synthase, GDP-mannose:dolichyl-phosphate mannosyltransferase, guanosine diphosphomannose-dolichol phosphate mannosyltransferase, dolichol phosphate mannose synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, GDP-mannose-dolichol phosphate mannosyltransferase, GDP-mannose-dolichylmonophosphate mannosyltransferase, mannosylphosphodolichol synthase, and mannosylphosphoryldolichol synthase. This enzyme participates in n-glycan biosynthesis.

References

• Babczinski P, Haselbeck A, Tanner W (1980). "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme". Eur. J. Biochem. 105 (3): 509–15. doi:10.1111/j.1432-1033.1980.tb04526.x. PMID 6989607. 
• Bretthauer RK, Wu S, Irwin WE (1973). "Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis". Biochim. Biophys. Acta. 304 (3): 736–47. PMID 4726855. 
• Haselbeck A (1989). "Purification of GDP mannose:dolichyl-phosphate O-beta-D-mannosyltransferase from Saccharomyces cerevisiae". Eur. J. Biochem. 181 (3): 663–8. doi:10.1111/j.1432-1033.1989.tb14774.x. PMID 2659345. 
• Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W (1980). "Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives". Eur. J. Biochem. 105 (3): 517–23. doi:10.1111/j.1432-1033.1980.tb04527.x. PMID 6445267. 
• Richards JB, Hemming FW (1972). "The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum". Biochem. J. 130 (1): 77–93. PMC 1174303. PMID 4655455. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1174303. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.4.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase Paola S. Timiras Look at other dictionaries: Dolichyl-phosphate-mannose-protein mannosyltransferase — Identifiers EC number 2.4.1.109 CAS number 74315 99 4 …   Wikipedia Dolichyl — Dolichyl, related to Dolichol, is used in the names of: Dolichyl beta D glucosyl phosphate, a molecule involved in glycosylation Dolichyl diphosphate polyphosphate phosphotransferase (EC 2.7.4.20) Dolichyl diphosphooligosaccharide protein… …   Wikipedia Mannosyltransferase — A mannosyltransferase is a type of glycosyltransferase that acts upon mannose.[1] An example is heteroglycan alpha mannosyltransferase. References ^ MeSH Mannosyltransferases …   Wikipedia DPM3 — Dolichyl phosphate mannosyltransferase polypeptide 3 Identifiers Symbols DPM3; CDG1O; MGC125904; MGC125905; MGC34275 External IDs …   Wikipedia DPM1 — Dolichyl phosphate mannosyltransferase polypeptide 1, catalytic subunit Identifiers Symbols DPM1; CDGIE; MPDS External IDs …   Wikipedia DPM2 — Dolichyl phosphate mannosyltransferase polypeptide 2, regulatory subunit Identifiers Symbols DPM2; FLJ80013; MGC111193; MGC21559 External IDs …   Wikipedia Dolichol monophosphate — Preferred IUPAC name [3,7,11,15,19 pentamethylicosa 6,10,14,18 tetraenyl] dihydrogen phosphate …   Wikipedia Glycogen phosphorylase — Phosphorylase The crystal structure of the rabit muscle glycogen phosphorylase AMP complex. AMP allosteric site (yellow), phosporylated Ser14 (orange), glycogen binding site (blue), catalytic site (red).[1] …   Wikipedia Purine nucleoside phosphorylase — Not to be confused with polynucleotide phosphorylase. purine nucleoside phosphorylase Identifiers EC number 2.4.2.1 CAS number …   Wikipedia Poly ADP ribose polymerase — For the sound, see Parp (onomatopoeic). ADP ribose …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”