Beta-galactoside alpha-2,3-sialyltransferase

In enzymology, a beta-galactoside alpha-2,3-sialyltransferase (EC number|2.4.99.4) is an enzyme that catalyzes the chemical reaction

:CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R $ightleftharpoons$ CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-, and galactosaminyl-R.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase. This enzyme participates in 7 metabolic pathways: o-glycan biosynthesis, keratan sulfate biosynthesis, glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - globoseries, glycosphingolipid biosynthesis - ganglioseries, glycan structures - biosynthesis 1, and glycan structures - biosynthesis 2.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2EX0, PDB link|2EX1, PDB link|2IHJ, PDB link|2IHK, PDB link|2IHZ, PDB link|2II6, PDB link|2IIB, PDB link|2IIQ, and PDB link|2ILV.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|71124-51-1."

Gene Ontology (GO) codes