Ribosomal frameshift

A ribosomal frameshift allows alternative translation of a mRNA sequence by changing the open reading frame. It is commonly found in viruses including barley yellow dwarf viruscite journal |author=Vincent JR, Lister RM, Larkins BA |title=Nucleotide sequence analysis and genomic organization of the NY-RPV isolate of barley yellow dwarf virus |journal=J. Gen. Virol. |volume=72 ( Pt 10) |issue= |pages=2347–55 |year=1991 |month=October |pmid=1840612 |doi= |url=http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=1840612] , potato leafroll viruscite journal |author=Kujawa AB, Drugeon G, Hulanicka D, Haenni AL |title=Structural requirements for efficient translational frameshifting in the synthesis of the putative viral RNA-dependent RNA polymerase of potato leafroll virus |journal=Nucleic Acids Res. |volume=21 |issue=9 |pages=2165–71 |year=1993 |month=May |pmid=8502558 |pmc=309480 |doi= |url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=8502558] and simian retrovirus-1cite journal |author=Sung D, Kang H |title=Mutational analysis of the RNA pseudoknot involved in efficient ribosomal frameshifting in simian retrovirus-1 |journal=Nucleic Acids Res. |volume=26 |issue=6 |pages=1369–72 |year=1998 |month=March |pmid=9490779 |pmc=147434 |doi= |url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=9490779] . Ribosomal frameshifting is promoted by a pseudoknot structure and slippery sequence (usually UUUAAAC)cite journal |author=Meulenberg JJ, Hulst MM, de Meijer EJ, "et al" |title=Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV |journal=Virology |volume=192 |issue=1 |pages=62–72 |year=1993 |month=January |pmid=8517032 |doi=10.1006/viro.1993.1008 |url=] . It is often required for translation of putative RNA-dependent RNA polymerase.

See also

* Translational frameshift
* HIV_Ribosomal_frameshift_signal

References