HIV Ribosomal frameshift signal

HIV Ribosomal frameshift signal

The HIV Ribosomal frameshift signal is an RNA element. HIV uses a system called -1 ribosomal frameshifting to produce the required ratio of Gag and Gag-Pol polyproteins. The stem-loop structure of the frameshift signal is thought to impede the ribosome and cause slippage in the 5' direction, this causes the -1 frameshift and translation then continues in the new frame. [cite journal | last = Biswas | first = P | coauthors = Jiang X, Pacchia AL, Dougherty JP, Peltz SW | year = 2004 | title = The human immunodeficiency virus type 1 ribosomal frameshifting site is an invariant sequence determinant and an important target for antiviral therapy | journal = J Virol | volume = 78 | pages = 2082–2087 | pmid = 14747573 | doi = 10.1128/JVI.78.4.2082-2087.2004]

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