Small nucleolar RNA SNORA73

In molecular biology, the small nucleolar RNA SNORA73 (also called U17/E1 RNA) belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS). [cite journal | last = Enright | first = CA | coauthors = Maxwell ES, Eliceiri GL, Sollner-Webb B | year = 1996 | title = 5'ETS rRNA processing facilitated by four small RNAs: U14, E3, U17, and U3 | journal = RNA | volume = 2 | pages = 1094–1099 | pmid = 8903340] This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms. [cite journal | last = Cervelli | first = M | coauthors = Cecconi F, Giorgi M, Annesi F, Oliverio M, Mariottini P | year = 2002 | title = Comparative Structure Analysis of Vertebrate U17 Small Nucleolar RNA (snoRNA) | journal = J Mol Evol | volume = 54 | pages = 166–179 | pmid = 11821910 | doi = 10.1007/s00239-001-0065-2]

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