Small nucleolar RNA SNORA74

Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. [cite journal | last = Ganot | first = P | coauthors = Caizergues-Ferrer M, Kiss T | year = 1997 | title = The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation | journal = Genes Dev | volume = 11 | pages = 941–956 | pmid = 9106664 | doi = 10.1101/gad.11.7.941] Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing. [cite journal | last = Kiss | first = T | coauthors = Bortolin ML, Filipowicz W | year = 1996 | title = Characterization of the intron-encoded U19 RNA, a new mammalian small nucleolar RNA that is not associated with fibrillarin | journal = Mol Cell Biol | volume = 16 | pages = 1391–1400 | pmid = 8657112] [cite journal | last = Bortolin | first = ML | coauthors = Kiss T | year = 1998 | title = Human U19 intron-encoded snoRNA is processed from a long primary transcript that possesses little potential for protein coding | journal = RNA | volume = 4 | pages = 445–454 | pmid = 9630250]

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