Lovastatin nonaketide synthase

In enzymology, a lovastatin nonaketide synthase (EC number|2.3.1.161) is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H⁺ + S-adenosyl-L-methionine $ightleftharpoons$ dihydromonacolin L + 9 CoA + 8 CO₂ + 11 NADP⁺ + S-adenosyl-L-homocysteine + 6 H₂O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H⁺, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO₂, NADP⁺, S-adenosyl-L-homocysteine, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|235426-97-8."

Gene Ontology (GO) codes