Aralkylamine N-acetyltransferase

In enzymology, an aralkylamine N-acetyltransferase (EC number|2.3.1.87) is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + a 2-arylethylamine $ightleftharpoons$ CoA + an N-acetyl-2-arylethylamine

Thus, the two substrates of this enzyme are acetyl-CoA and 2-arylethylamine, whereas its two products are CoA and N-acetyl-2-arylethylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:2-arylethylamine N-acetyltransferase. Other names in common use include serotonin acetyltransferase, serotonin acetylase, arylalkylamine N-acetyltransferase, serotonin N-acetyltransferase, AANAT, and melatonin rhythm enzyme. This enzyme participates in tryptophan metabolism.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B6B, PDB link|1IB1, PDB link|1KUV, PDB link|1KUX, PDB link|1KUY, and PDB link|1L0C.

AANAT inhibitors

Synthetic inhibitors of the enzyme have been discovered. [PMID 17924613 , PMID 14717709 , PMID 12943195 , PMID 12941292]

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|92941-56-5."

Gene Ontology (GO) codes