Aminoglycoside N6'-acetyltransferase

In enzymology, an aminoglycoside N6'-acetyltransferase (EC number|2.3.1.82) is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + kanamycin-B $ightleftharpoons$ CoA + N₆'-acetylkanamycin-B

Thus, the two substrates of this enzyme are acetyl-CoA and kanamycin B, whereas its two products are CoA and N6'-acetylkanamycin-B.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:kanamycin-B N6'-acetyltransferase. Other names in common use include aminoglycoside 6'-N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6-N-acetyltransferase, and kanamycin acetyltransferase.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1S3Z, PDB link|1S5K, PDB link|1S60, and PDB link|2A4N.

References

*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|56467-65-3."

Gene Ontology (GO) codes