6-methylsalicylic-acid synthase

6-methylsalicylic-acid synthase

In enzymology, a 6-methylsalicylic-acid synthase (EC number|2.3.1.165) is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + 3 malonyl-CoA + NADPH + H+ ightleftharpoons 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O

The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H+, whereas its 5 products are 6-methylsalicylate, CoA, CO2, NADP+, and H2O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing). Other names in common use include MSAS, and 6-methylsalicylic acid synthase.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9045-37-8."

Gene Ontology (GO) codes


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