Nicotinamide-nucleotide amidase

nicotinamide-nucleotide amidase
Identifiers
EC number	3.5.1.42
CAS number	37355-58-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nicotinamide-nucleotide amidase (EC 3.5.1.42) is an enzyme that catalyzes the chemical reaction

beta-nicotinamide D-ribonucleotide + H₂O $\rightleftharpoons$ beta-nicotinate D-ribonucleotide + NH₃

Thus, the two substrates of this enzyme are beta-nicotinamide D-ribonucleotide and H₂O, whereas its two products are beta-nicotinate D-ribonucleotide and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide-D-ribonucleotide amidohydrolase. Other names in common use include NMN deamidase, nicotinamide mononucleotide deamidase, and nicotinamide mononucleotide amidohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.

References

• Imai T (Tokyo). "Purification and properties of nicotinamide mononucleotide amidohydrolase from Azotobacter vinelandii". J. Biochem. (1): 139–53. PMID 4144084. 

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