- Oleoyl-(acyl-carrier-protein) hydrolase
acyl-ACP thioesterase Identifiers EC number 220.127.116.11 CAS number 68009-83-6 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles
In enzymology, an oleoyl-[acyl-carrier-protein] hydrolase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reaction
- oleoyl-[acyl-carrier-protein] + H2O [acyl-carrier-protein] + oleate
Thus, the two substrates of this enzyme are [[oleoyl-[acyl-carrier-protein]]] and H2O, whereas its two products are acyl-carrier-protein and oleate.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is oleoyl-[acyl-carrier-protein] hydrolase. Other names in common use include acyl-[acyl-carrier-protein] hydrolase, acyl-ACP-hydrolase, acyl-acyl carrier protein hydrolase, oleoyl-ACP thioesterase, and oleoyl-acyl carrier protein thioesterase. This enzyme participates in fatty acid biosynthesis.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2OWN and 2PFF.
- Ohlrogge JB, Shine WE, Stumpf PK (1978). "Fat metabolism in higher plants. Characterization of plant acyl-ACP and acyl-CoA hydrolases". Arch. Biochem. Biophys. 189 (2): 382–91. doi:10.1016/0003-9861(78)90225-4. PMID 30409.
- Shine WE, Mancha M, Stumpf PK (1976). "Fat metabolism in higher plants. The function of acyl thioesterases in the metabolism of acyl-coenzymes A and acyl-acyl carrier proteins". Arch. Biochem. Biophys. 172 (1): 110–6. doi:10.1016/0003-9861(76)90054-0. PMID 3134.
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