Cephalosporin-C deacetylase

Cephalosporin-C deacetylase
cephalosporin-C deacetylase
Identifiers
EC number 3.1.1.41
CAS number 52227-71-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cephalosporin-C deacetylase (EC 3.1.1.41) is an enzyme that catalyzes the chemical reaction

cephalosporin C + H2O \rightleftharpoons deacetylcephalosporin C + acetate

Thus, the two substrates of this enzyme are cephalosporin C and H2O, whereas its two products are deacetylcephalosporin C and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cephalosporin-C acetylhydrolase. Other names in common use include cephalosporin C acetyl-hydrolase, cephalosporin C acetylase, cephalosporin acetylesterase, cephalosporin C acetylesterase, cephalosporin C acetyl-esterase, and cephalosporin C deacetylase. This enzyme participates in penicillin and cephalosporin biosynthesis.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1L7A, 1ODS, 1ODT, and 1VLQ.

References

  • Fujisawa Y, Shirafugi H, Kida M, Nara K, Yoneda M, Kanzaki T (1973). "New findings on cephalosporin C biosynthesis". Nat. New. Biol. 246 (153): 154–5. PMID 4519146. 
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