Channel-conductance-controlling ATPase

Channel-conductance-controlling ATPase
channel-conductance-controlling ATPase
Identifiers
EC number 3.6.3.49
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a channel-conductance-controlling ATPase (EC 3.6.3.49) is an enzyme that catalyzes the chemical reaction

ATP + H2O \rightleftharpoons ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (channel-conductance-controlling).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XMI and 1XMJ.

References

  • Chen M, Zhang JT (1996). "Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes". Mol. Membr. Biol. 13 (1): 33–40. doi:10.3109/09687689609160572. PMID 9147660. 
  • Tusnady GE, Bakos E, Varadi A, Sarkadi B (1997). "Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters". FEBS. Lett. 402 (1): 1–3. doi:10.1016/S0014-5793(96)01478-0. PMID 9013845. 
  • Sheppard DN, Welsh MJ (1999). "Structure and function of the CFTR chloride channel". Physiol. Rev. 79 (1 Suppl): S23–45. PMID 9922375.