Hydroxyacylglutathione hydrolase
- Hydroxyacylglutathione hydrolase
In enzymology, a Hydroxyacylglutathione hydrolase (EC number|3.1.2.6) is an enzyme that catalyzes the chemical reaction
:(R)-S-lactoylglutathione + water glutathione + a 2-hydroxy carboxylate
Hence, this enzyme has two substrate, (R)-S-lactoylglutathione and water, and two products, glutathione and a 2-hydroxy carboxylate. With the common substrate methylglyoxal, the product is D-lactate. [cite journal |author=Vander Jagt DL |title=Glyoxalase II: molecular characteristics, kinetics and mechanism |journal=Biochem. Soc. Trans. |volume=21 |issue=2 |pages=522–7 |year=1993 |pmid=8359524]
This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases. This enzyme is commonly known asglyoxylase II. This enzyme participates in pyruvate metabolism.
References
*cite journal |author=Ball JC, Vander Jagt DL |title=Purification of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from rat erythrocytes |journal=Anal. Biochem. |volume=98 |issue=2 |pages=472–7 |year=1979 |pmid=496013 |doi=10.1016/0003-2697(79)90169-6
External links
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Look at other dictionaries:
hydroxyacylglutathione hydrolase — An enzyme with catalytic activity similar to that of lactoylglutathione lyase, but more general; catalyzes the hydrolysis of an S 2 hydroxyacylglutathione, producing glutathione and a 2 hydroxy acid anion. SEE ALSO: glyoxalase. * * *… … Medical dictionary
hydroxyacylglutathione hydrolase — noun An enzyme involved in pyruvate metabolism … Wiktionary
HAGH — Hydroxyacylglutathione hydrolase, also known as HAGH, is a human gene.cite web | title = Entrez Gene: HAGH hydroxyacylglutathione hydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3029| accessdate … Wikipedia
List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… … Wikipedia
glyoxalase — An enzyme, lactoylglutathione lyase (g. I) or hydroxyacylglutathione hydrolase (g. II), in red cells and other tissues that converts glyoxal and substituted glyoxals bound to glutathione into the corresponding free hydroxy acid s (g. II) or… … Medical dictionary
