3-dehydroquinate dehydratase

In enzymology, a 3-dehydroquinate dehydratase (EC number|4.2.1.10) is an enzyme that catalyzes the chemical reaction

:3-dehydroquinate $ightleftharpoons$ 3-dehydroshikimate + H₂O

Hence, this enzyme has one substrate, 3-dehydroquinate, and two products, 3-dehydroshikimate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming). Other names in common use include 3-dehydroquinate hydrolase, DHQase, dehydroquinate dehydratase, 3-dehydroquinase, 5-dehydroquinase, dehydroquinase, 5-dehydroquinate dehydratase, 5-dehydroquinate hydro-lyase, and 3-dehydroquinate hydro-lyase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

tructural studies

As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1D0I, PDB link|1GQN, PDB link|1GQO, PDB link|1GTZ, PDB link|1GU0, PDB link|1GU1, PDB link|1H05, PDB link|1H0R, PDB link|1H0S, PDB link|1J2Y, PDB link|1L9W, PDB link|1QFE, PDB link|1SFJ, PDB link|1SFL, PDB link|1UQR, PDB link|1V1J, PDB link|2BT4, PDB link|2C4V, PDB link|2C4W, PDB link|2C57, PDB link|2CJF, PDB link|2DHQ, PDB link|2EGZ, PDB link|2GPT, PDB link|2OCZ, and PDB link|2YR1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9012-66-2."

Gene Ontology (GO) codes